Recent trends and challenges to overcome Pseudomonas aeruginosa infections [0.03%]
近年假单胞菌感染的流行趋势及应对挑战
Alessandra Ammazzalorso,Arianna Granese,Barbara De Filippis
Alessandra Ammazzalorso
Introduction: Pseudomonas aeruginosa (PA) is a Gram-negative bacterium that can cause a wide range of severe infections in immunocompromised patients. The most difficult challenge is due to its ability to rapidly develop ...
Targeting the TGF-β signaling pathway: an updated patent review (2021-present) [0.03%]
靶向转化生长因子-β信号通路：2021年至今专利回顾更新
Wenhao Guo,Hanwen Liu,Yong Yan et al.
Wenhao Guo et al.
Introduction: The TGF-β signaling pathway is a complex network that plays a crucial role in regulating essential biological functions and is implicated in the onset and progression of multiple diseases. This review highl...
Enrico Mario Alessandro Fassi,Andrea Citarella,Marco Albani et al.
Enrico Mario Alessandro Fassi et al.
Introduction: Proprotein convertase subtilisin/kexin 9 (PCSK9) plays a crucial role in breaking down the hepatic low-density lipoprotein receptor (LDLR), thereby influencing the levels of circulating low-density lipoprote...
An overview on recent patents and technologies on nanoparticles for nucleic acid delivery [0.03%]
核酸输送纳米颗粒最近专利和技术综述
Larissa Moraes Dos Santos Fonseca,Bruna Aparecida Souza Machado,Fabricia Oliveira Oliveira et al.
Larissa Moraes Dos Santos Fonseca et al.
Introduction: Nucleic acid-based therapeutics offer groundbreaking potential for treating genetic diseases and advancing next-generation vaccines. Despite their promise, challenges in efficient delivery persist due to the...
Synthetic lethality: targeting SMARCA2 ATPase in SMARCA4-deficient tumors - a review of patent literature from 2019-30 June 2023 [0.03%]
合成致死性：靶向SMARCA4缺陷型肿瘤中的SMARCA2 ATP酶——2019年至今专利文献综述
Kyle D Reichl,Esther C Y Lee,Ariamala Gopalsamy
Kyle D Reichl
Introduction: The multi-subunit SWI/SNF chromatin remodeling complex is a key epigenetic regulator for many cellular processes, and several subunits are found to be mutated in human cancers. The inactivating mutations of ...
Valentina Puca,Beatrice Marinacci,Benedetta Pellegrini et al.
Valentina Puca et al.
Introduction: Bacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components of Extracellular Polymeric Substances (EPS) b...
Targeting the relaxin-3/RXFP3 system: a patent review for the last two decades [0.03%]
松弛素-3/RXFP3系统的靶向作用：过去二十年的专利回顾
Md Toufiqur Rahman,Hetti Handi Chaminda Lakmal,Javeena Hussain et al.
Md Toufiqur Rahman et al.
Introduction: The neuropeptide relaxin-3/RXFP3 system belongs to the relaxin/insulin superfamily and is involved in many important physiological processes, such as stress responses, appetite control, and motivation for re...
Targeting the PI3K/AKT signaling pathway in anticancer research: a recent update on inhibitor design and clinical trials (2020-2023) [0.03%]
PI3K/AKT信号通路在抗癌研究中的靶向作用：关于抑制剂设计和临床试验的最新进展（2020-2023）
Dima A Sabbah,Rima Hajjo,Sanaa K Bardaweel et al.
Dima A Sabbah et al.
Introduction: Recent years have witnessed great achievements in drug design and development targeting the phosphatidylinositol 3-kinase/protein kinase-B (PI3K/AKT) signaling pathway, a pathway central to cell growth and p...
Richa Raj,Pingping Shen,Boyang Yu et al.
Richa Raj et al.
Introduction: HMGB1 is a non-histone chromatin protein released or secreted in response to tissue damage or infection. Extracellular HMGB1, as a crucial immunomodulatory factor, binds with several different receptors to i...
Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery [0.03%]
碳酸酐酶和细菌代谢：抗菌药物发现的机会
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Introduction: Carbonic anhydrases (CAs, EC 4.2.1.1) play a pivotal role in the regulation of carbon dioxide , bicarbonate, and hydrogen ions within bacterial cells, ensuring pH homeostasis and facilitating energy producti...