Innovative approaches for managing relapsed or refractory peripheral T-cell lymphoma [0.03%]
复发或难治外周T细胞淋巴瘤的创新管理方法
Brian T Grainger,Joshua Casan,Chathuri Abeyakoon et al.
Brian T Grainger et al.
Introduction: Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of hematologic malignancies arising from mature, post-thymic T- and natural killer (NK) cells. This review explores innovative approaches to mana...
Is supplemental vitamin D useful in the clinically isolated syndrome (CIS) typical of multiple sclerosis? [0.03%]
维生素D作为单相综合症（多发性硬化前期）的辅助治疗有效吗？
Sheila A Doggrell
Sheila A Doggrell
Introduction: Although vitamin D deficiency is a risk factor for multiple sclerosis (MS), vitamin D has only limited benefit in MS. It is now being considered in clinically isolated syndrome (CIS) prior to MS. ...
Pharmacotherapeutic landscape for the management of agitation associated with Alzheimer's disease [0.03%]
阿尔茨海默病相关躁动的药物治疗格局
Samir Jain,Ece Buyuksandalyaci Tunc,George T Grossberg
Samir Jain
Introduction: Agitation associated with Alzheimer's disease (AAD) is common, persistent, and strongly linked to caregiver burden, emergency care, and institutionalization. Pharmacologic options have historically been limi...
Phenotypic response surface-guided pharmacotherapy for personalized combination treatment in complex diseases [0.03%]
表型响应面指导的精准药物治疗复杂疾病个性化联合用药疗法
Atif Ali Khan Khalil,Muhammad Saeed Akhtar,Wajid Zaman et al.
Atif Ali Khan Khalil et al.
Introduction: Optimizing multidrug regimens for complex diseases remains a major challenge in precision medicine because responses are shaped by interpatient heterogeneity, nonlinear drug interactions, and incomplete mech...
New perspectives in managing chronic pelvic pain in endometriosis: the role of GnRH antagonists versus dienogest [0.03%]
子宫内膜异位症慢性盆腔痛的管理新视角：GnRH拮抗剂与地诺孕素的作用机制比较
Mario Palumbo,Pierluigi Giampaolino,Massimiliano Pellicano et al.
Mario Palumbo et al.
Introduction: Endometriosis is a chronic, estrogen-dependent inflammatory disease affecting about 10% of reproductive-age women. Chronic pelvic pain is its most disabling symptom, and available therapies often show limite...
Barbara Pokora,Kacper Pokora,Jakub Fichna
Barbara Pokora
Introduction: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid malignancies, driven by aggressive tumor biology, therapeutic resistance, and activation of oncogenic KRAS. Despite advances in ch...
Jack Shi Jie Yuan-Doré,Lucia Yin,Syed Haider Tahir et al.
Jack Shi Jie Yuan-Doré et al.
Introduction: Difficult-to-manage (D2M) axial spondyloarthritis (axSpA) is a recently published Assessment of SpondyloArthritis International Society (ASAS) consensus definition, defined by persistent symptoms despite 2 o...
Psychedelic-assisted pharmacotherapy: clinical applications and regulatory considerations [0.03%]
psychedelia辅助药物治疗：临床应用与监管考量
Donatella Marazziti,Matteo Gambini,Riccardo Gurrieri et al.
Donatella Marazziti et al.
Introduction: After decades of regulatory marginalization, psychedelic compounds have reemerged as promising therapeutic tools in psychiatry, driven by unmet clinical needs in treatment-resistant mental disorders and by g...
Emerging treatments in hypertrophic cardiomyopathy: a focus on cardiac myosin inhibitors [0.03%]
肥厚型心肌病的新兴疗法：关注心脏肌球蛋白抑制剂
Stuti Shah,Mohammed Abusafia,Susan Keen et al.
Stuti Shah et al.
Introduction: Hypertrophic cardiomyopathy (HCM) is commonly driven by sarcomeric hypercontractility and may cause dynamic left ventricular outflow tract obstruction (LVOTO). Conventional therapies reduce symptoms and hemo...
Optimizing the use of novel systemic therapies in atopic dermatitis: an insight into therapeutic transitions [0.03%]
关注特应性皮炎系统新药治疗的优化和转换
Elena Ippoliti,Giulia Coscarella,Luisa Boeti et al.
Elena Ippoliti et al.