Oral selective estrogen receptor degraders (SERDs) for the treatment of hormone receptor-positive, HER2-negative breast cancer title: oral selective estrogen receptor degraders (SERDs) for the treatment of hormone receptor-positive, HER2-negative breast cancer [0.03%]
口服选择性雌激素受体降解剂（SERD）治疗激素受体阳性、HER2阴性的乳腺癌
Julian David Etessami,Carmine Valenza,Pier Paolo Maria Berton Giachetti et al.
Julian David Etessami et al.
Introduction: Endocrine therapy (ET) remains the backbone of treatment for hormone receptor-positive (HR+), HER2-negative breast cancer. However, resistance, frequently driven by acquired ESR1 mutations detected in up to ...
Acute severe ulcerative colitis: efficacy and safety of JAK inhibitors [0.03%]
急性重度溃疡性结肠炎：JAK抑制剂的疗效和安全性
Alessandro Bruno,Sarah Bencardino,Ferdinando D&#x;Amico et al.
Alessandro Bruno et al.
Introduction: Acute severe ulcerative colitis is a potentially life-threatening manifestation of ulcerative colitis requiring hospitalization and prompt intervention. Despite corticosteroids being the cornerstone of initi...
Maya Bhattiprolu,Max Kappler,Tae-Un Han et al.
Maya Bhattiprolu et al.
Introduction: Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder that results in the accumulation of glucosylceramide (GluCer) within macrophages. Current treatments for GD include enzyme replacemen...
What is the emerging role of RNA interference in HBV cure strategies? [0.03%]
RNA干扰在HBV功能性治愈策略中扮演怎样的角色？
Zillah Cargill,Kosh Agarwal
Zillah Cargill
Pharmacotherapeutic approaches to treating postpartum depression: a focus on GABAA receptor positive allosteric modulators [0.03%]
产后抑郁症的药理治疗手段——以GABAA受体阳性 allosteric模体为重点的研究
Anne Louise Stewart,Eleanor Blair Towers,Elizabeth S Wenzel et al.
Anne Louise Stewart et al.
Introduction: Postpartum depression (PPD) is a common psychiatric illness with significant consequences for both mother and infant. The approval of brexanolone in 2019 introduced a novel mechanism of antidepressant action...
Glucocorticoid therapy and risk of venous thromboembolism: a systematic review and meta-analysis with exploration of dose, duration, and route-specific Effects [0.03%]
糖皮质激素治疗与静脉血栓栓塞风险的关联：剂量、持续时间及途径特异性效应的系统评价和meta分析
Narat Srivali,Federica De Giacomi
Narat Srivali
Introduction: Glucocorticoids (GCs) are among the most widely prescribed medications globally. Despite biological plausibility for procoagulant effects, the magnitude of venous thromboembolism (VTE) risk has not been rigo...
Orforglipron and the emergence of oral GLP-1 therapy for obesity: efficacy, safety, and clinical positioning [0.03%]
口服GLP-1药物或forglipron用于肥胖治疗的疗效、安全性及临床定位
Wajid Zaman,Adnan Amin
Wajid Zaman
Introduction: Obesity is a chronic, relapsing disease associated with substantial cardiometabolic morbidity and reduced quality of life. Although pharmacotherapy has advanced rapidly, current treatment options remain limi...
Niels Frimodt-Möller,Frederik Boetius Hertz
Niels Frimodt-Möller
Introduction: Pivmecillinam is the oral prodrug of mecillinam. Following absorption, the pivaloyl ester is hydrolyzed, releasing the active mecillinam into systemic circulation. It is a narrow spectrum aminopenicillin ant...
The complexities of the pharmacotherapeutic management of chronic hepatitis C virus infection in hepatocellular carcinoma patients [0.03%]
慢性丙型肝炎病毒感染合并肝细胞癌患者的药物治疗管理的复杂性
Nicola Schiano Moriello,Biagio Pinchera,Ivan Gentile
Nicola Schiano Moriello
Introduction: Hepatocellular carcinoma represents a relevant cause of cancer mortality globally, with hepatitis C virus infection accounting for 25-30% of cases. The advent of direct-acting antivirals has transformed HCV ...
The challenges and practical considerations with optimizing neonatal pharmacotherapy [0.03%]
新生儿药物治疗优化的挑战与实际考虑因素
M A Turner
M A Turner
Introduction: Optimal neonatal pharmacotherapy requires the implementation of high-quality information about medicines. Areas covered: ...