Jacquie R Baker,Satish R Raj
Jacquie R Baker
Background: Orthostatic hypotension remains one of the most disabling manifestations of autonomic failure. Current therapies can improve upright blood pressure and orthostatic tolerance, but treatment is often limited by ...
Role of hormonal therapies in endometriosis: balancing efficacy and safety [0.03%]
平衡疗效与安全性的激素疗法在子宫内膜异位症治疗中的作用
Simone Ferrero,Michele Paudice,Umberto Perrone et al.
Simone Ferrero et al.
Introduction: Endometriosis is a chronic, estrogen-dependent inflammatory disorder requiring long-term management strategies that balance efficacy with systemic safety. Although hormonal therapies remain the cornerstone o...
How are developments in the treatment armamentarium of hyperphosphatemia addressing the current therapeutic challenges? [0.03%]
高磷血症治疗手段的最新进展如何应对当前的治疗挑战？
Lorenza Magagnoli,Paola Ciceri,Mario Cozzolino
Lorenza Magagnoli
Targeted therapies in thoracic neuroendocrine tumors: challenges and failures of tyrosine kinase inhibition in lung and thymic carcinoids [0.03%]
肺和胸腺类癌酪氨酸激酶抑制治疗的挑战与困境——支气管神经内分泌肿瘤的靶向治疗
Alice Laffi,Chiara Catania,Martino De Pas et al.
Alice Laffi et al.
Introduction: Lung (LCs) and thymic carcinoids (ThCs) belong to thoracic well-differentiated neuroendocrine tumors (NETs), whose therapeutic options for advanced stages are limited. In the era of precision medicine, tyros...
Current and advanced therapeutic strategies for volume expansion management in heart failure [0.03%]
心力衰竭容量管理的当前及先进治疗策略
Miguel Lorenzo,Gonzalo Núñez-Marín,Marco Montomoli et al.
Miguel Lorenzo et al.
Introduction: Congestion and/or volume expansion is primary driver of adverse outcomes in patients with heart failure. Despite the widespread use of loop diuretics as first-line therapy, diuretic resistance frequently lim...
An update on recent developments in the drug treatment of tuberculous meningitis [0.03%]
结核性脑膜炎药物治疗的最新进展更新
Robert M Gray,Sean Wasserman,Robert J Wilkinson
Robert M Gray
Introduction: Tuberculous Meningitis (TBM) is an often lethal form of tuberculosis with damage to the brain resulting from a combination of direct effects from the causative pathogen M. tuberculosis and from the host infl...
Injectable long-acting pre-exposure prophylaxis for HIV prevention: advancements and future directions in pharmacotherapy [0.03%]
艾滋病预防的长效预暴露防护注射疗法：药物治疗的进展与未来方向
Angelo Roberto Raccagni,Antonella Castagna,Silvia Nozza
Angelo Roberto Raccagni
Introduction: Long-acting (LA) injectable pre-exposure prophylaxis (PrEP) expands HIV prevention choice beyond daily oral tenofovir-based regimens and may improve persistence by decoupling protection from daily pill-takin...
Debopam Samanta
Debopam Samanta
Introduction: Angelman syndrome (AS) is a neurodevelopmental disorder arising from loss of maternal UBE3A function, characterized by intellectual disability, absent speech, ataxic gait, and epilepsy in 80-90% of patients....
From covalent to reversible: the expanding role of BTK inhibitors in chronic lymphocytic leukemia [0.03%]
从共价到可逆：BTK抑制剂在慢性淋巴细胞白血病中角色的扩展
Tadeusz Robak
Tadeusz Robak
Introduction: BTK inhibitors are divided into two groups based on their binding mechanism: covalent, irreversible (cBTKis), and non-covalent, reversible BTK inhibitors (ncBTKis). The covalent BTK inhibitors approved for u...
The role of cardiac myosin activators in dilated cardiomyopathy pharmacotherapy [0.03%]
心肌活化剂在扩张型心肌病药物治疗中的作用
Elenea Salas Garcia,Matthew R G Taylor,Luisa Mestroni et al.
Elenea Salas Garcia et al.