Evaluation of delgocitinib for the treatment of moderate to severe chronic hand eczema in adults [0.03%]
德加西替尼治疗成人中重度手部湿疹的疗效评估
Nicole Piaskowski,Philipp Globig,Margitta Worm
Nicole Piaskowski
Introduction: Chronic hand eczema (CHE) is a frequent inflammatory skin disorder associated with a substantial psychosocial and economic burden. Its prevalence ranges from 4.7% up to 10%. The therapeutic management of CHE...
Evaluating linaclotide for the treatment of irritable bowel syndrome with constipation in children and adolescents [0.03%]
林普罗司特治疗儿童及青少年便秘性肠易综合征疗效评估研究
Manuel Linares,Miguel Saps
Manuel Linares
Introduction: Irritable bowel syndrome with constipation (IBS-C) is a common pediatric disorder of gut - brain interaction (DGBI) characterized by constipation-related bowel dysfunction and recurrent abdominal pain. Despi...
Pharmacological treatment of anhedonic depression: the role of dopaminergic and anti-inflammatory mechanisms [0.03%]
药理学治疗抑郁性欣快感缺失：多巴胺能和抗炎机制的作用
Daniel Lindqvist
Daniel Lindqvist
Alessia Romano,Giovanna Fernanda Vazzana,Claudio Romano
Alessia Romano
Introduction: Pediatric ulcerative colitis (UC) is a chronic, immune-mediated inflammatory disease of the colon, characterized by dysregulated immune response. This condition significantly impacts growth, development, and...
The rise and fall of TRPV1-targeted analgesia in osteoarthritis: a critical appraisal [0.03%]
骨关节炎TRPV1靶向镇痛疗法的兴衰：批判性评价
Matta Csaba,Roland Takács,Eun-Jung Jin et al.
Matta Csaba et al.
Introduction: Transient receptor potential vanilloid 1 (TRPV1) has been pursued as a therapeutic target in osteoarthritis (OA) pain for over two decades. Both systemic antagonism and localized agonism advanced into clinic...
Dopamine transporter and beyond: evolving targets and combination strategies in stimulant use disorder [0.03%]
多巴胺转运蛋白等：兴奋剂使用障碍的治疗靶点及联合策略的发展演变
Ike de la Peña,Justin Row,Wei-Xing Shi
Ike de la Peña
Introduction: Stimulant use disorder (StUD), including cocaine and methamphetamine use disorders, remains a major unmet clinical need with no approved pharmacotherapies. Despite strong mechanistic rationale, dopamine tran...
GnRH antagonists for the treatment of fibroids and adenomyosis, current evidence and future perspectives [0.03%]
治疗子宫肌瘤和腺肌症的 GnRH 拮抗剂：现有证据及未来展望
Simone Ferrero,Irene Gazzo,Umberto Perrone et al.
Simone Ferrero et al.
Introduction: Uterine fibroids and adenomyosis are common estrogen- and progesterone-dependent disorders associated with heavy menstrual bleeding, pelvic pain, anemia, and impaired quality of life. Although surgery remain...
Pharmacotherapeutic strategies for the management of congenital adrenal hyperplasia [0.03%]
先天性肾上腺增生的药物治疗策略
Wen Huey Goai,David J Torpy
Wen Huey Goai
Introduction: Classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is characterized by impaired cortisol synthesis and excess adrenal androgen production. Current management relies on ad...
CURRENT ADVANCES IN PHARMACOTHERAPEUTIC STRATEGIES FOR THE TREATMENT OF COMPLICATED INTRA-ABDOMINAL INFECTIONS [0.03%]
复杂腹内感染的药理治疗策略的最新进展
Philippe Montravers,Enora Atchade,Nathalie Zappella
Philippe Montravers
Introduction: Complicated intra-abdominal infections (cIAIs) represent a major cause of surgical emergencies, arising from community-acquired conditions or heathcare-associated complications. This review, based on literat...
Emerging synthetic drugs for the management of Hidradenitis Suppurativa: a comprehensive update [0.03%]
新的用于治疗汗腺炎的合成药物：全面更新
Daifallah Almansouri,Alaa Naasani,Christos C Zouboulis
Daifallah Almansouri
Introduction: Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disorder affecting intertriginous regions. Despite its substantial impact on quality of life and association with serious systemic c...