An evaluation of canagliflozin for the treatment of type 2 diabetes: an update [0.03%]
坎格列净治疗2型糖尿病的疗效和安全性：更新后证据的系统评价和 meta 分析
Taichi Minami,Akiko Kameda,Yasuo Terauchi
Taichi Minami
IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2is) are proven to ameliorate kidney and heart failure in patients with type 2 diabetes (T2D), in addition to improving glycemic controls. Canagliflozin is a SGLT2i and has proved b...
An overview of adapalene and benzoyl peroxide once-daily topical gel as a therapeutic option for acne [0.03%]
一次用药的 adapalene和苯扎氯铵凝胶治疗痤疮的效果观察
Veronica K Emmerich,Caitlin G Purvis,Steven R Feldman
Veronica K Emmerich
Introduction: Acne vulgaris is the most common skin condition worldwide, and it is associated with substantial psychological comorbidity. Topical therapies - including retinoids, antibiotics, and benzoyl peroxide - are th...
Pharmacotherapy for recurrent respiratory papillomatosis (RRP): a treatment update [0.03%]
复发性呼吸道乳头状瘤病的药物治疗进展报告更新
Adam J Donne,Andy Kinshuck
Adam J Donne
Introduction: Recurrent respiratory papillomatosis is a rare human papillomavirus (HPV)-induced condition where warts grow within the airway and especially the larynx to effect voice and restrict breathing.Areas covered: A PubMed search usi...
A pharmacoeconomic evaluation of pharmaceutical treatment options for prostate cancer [0.03%]
前列腺癌的药物治疗方案的药物流行病学评估
Mohamad Moussa,Athanasios Papatsoris,Despoina Sryropoulou et al.
Mohamad Moussa et al.
Introduction: Prostate cancer is one of the most common neoplasms in men. For many years the mainstay of treatment was androgen deprivation therapy, but during last decade many novel agents have emerged, accompanied by in...
An update on antithrombotic therapy in atrial fibrillation patients in long-term ambulatory setting after percutaneous coronary intervention: where do we go from here? [0.03%]
长期随访的经皮冠状动脉介入治疗后房颤患者的抗血栓治疗进展及未来展望
Jacopo Marazzato,Paolo Verdecchia,Michele Golino et al.
Jacopo Marazzato et al.
Introduction: In the treatment of patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention (PCI), it is unclear which combination of antithrombotic drugs is preferable and which is the optimal...
Vericiguat for the treatment of heart failure: mechanism of action and pharmacological properties compared with other emerging therapeutic options [0.03%]
维卡格普治疗心力衰竭的研究：与其它新兴治疗方法的机制和药理性质比较
Jean-Sébastien Hulot,Jean-Noël Trochu,Erwan Donal et al.
Jean-Sébastien Hulot et al.
Introduction: The significant morbidity and mortality in patients with heart failure (HF), notably in the most advanced forms of the disease, justify the need for novel therapeutic options. In the last year, the soluble g...
State-of-the-art, approved therapeutics for the pharmacological management of osteosarcoma [0.03%]
最新、最有效的药物治疗骨肉瘤的药理学管理方法
Cristina Meazza,Sebastian Dorin Asaftei
Cristina Meazza
Introduction: Advances in the treatment of osteosarcoma (OS) came in the mid-1970s, when adding chemotherapy to surgery significantly improved patient survival. OS outcomes have since plateaued, however, despite exhaustive clinical investig...
Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders? [0.03%]
药物治疗能否改善同时患有重大抑郁和可卡因使用障碍患者的效果？
Gustavo A Angarita,Hasti Hadizadeh,Ignacio Cerdena et al.
Gustavo A Angarita et al.
Introduction: Major depressive disorder (MDD) and cocaine use disorder (CUD) are prevalent and frequently co-occur. When co-occurring, the presence of one disorder typically negatively impacts the prognosis for the other. Given the clinical...
Molecular-based and antibody-based targeted pharmacological approaches in childhood acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病的分子靶向和抗体靶向治疗药物研发进展
Magalie Tardif,Amalia Souza,Maja Krajinovic et al.
Magalie Tardif et al.
Introduction: Despite the significant survival improvement in childhood acutelymphoblastic leukemia (ALL), 15-20% of patients continue to relapse; outcomes following relapse remain suboptimal and have room for further improvement. Advances ...
Vincent Chau,Ravi A Madan,Jeanny B Aragon-Ching
Vincent Chau
Introduction: Protein kinases have emerged as targetable pathways used in metastatic prostate cancer given their role in prostatic tumor growth, proliferation and metastases. Protein kinase inhibitors are small molecules ...