AVP-786 for the treatment of agitation in dementia of the Alzheimer's type [0.03%]
AVP-786治疗阿尔茨海默型痴呆所致激越
Ricardo P Garay,George T Grossberg
Ricardo P Garay
Agitation is common and distressing in patients with Alzheimer-type dementia, but safe, effective treatments remain elusive. Psychological treatments are first-line options, but they have limited efficacy. Off-label psychotropic medications...
RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials [0.03%]
RRx-001：一种非系统性毒性M2至M1巨噬细胞刺激和增敏剂II期临床试验
Bryan Oronsky,Ramasamy Paulmurugan,Kira Foygel et al.
Bryan Oronsky et al.
According to Hanahan and Weinberg, cancer manifests as six essential physiologic hallmarks: (1) self-sufficiency in growth signals, (2) insensitivity to growth-inhibitory signals, (3) evasion of programmed cell death, (4) limitless replicat...
Thomas Müller
Thomas Müller
An inherited, chronic progressive, neurodegenerative disorder is Huntington's disease, characterized by motor, cognitive, and psychiatric symptoms. Predictive genetic testing allows earlier diagnosis and identification of gene carriers for ...
Muscarinic antagonists in early stage clinical development for the treatment of asthma [0.03%]
在哮喘治疗中处于早期临床研发阶段的毒蕈碱受体拮抗剂
Timothy E Albertson,James A Chenoweth,Jason Y Adams et al.
Timothy E Albertson et al.
Parasympathetic neurons utilize the neurotransmitter acetylcholine to modulate and constrict airway smooth muscles at the muscarinic acetylcholine receptor. Inhaled agents that antagonize the muscarinic (M) acetylcholine receptor, particula...
Deepa S Subramaniam,Eiran A Warner,Giuseppe Giaccone
Deepa S Subramaniam
Heat shock proteins (Hsps) are part of a complex network of chaperone proteins that are critically involved in the conformational maturation of intracellular proteins and regulate their degradation via the proteasome system Hsps (especially...
Su-Hua Sha,Jochen Schacht
Su-Hua Sha
Noise-induced hearing loss (NIHL) due to industrial, military, and recreational noise exposure is a major, but also potentially preventable cause of acquired hearing loss. For the United States it is estimated that 26 million people (15% of...
Investigational hemagglutinin-targeted influenza virus inhibitors [0.03%]
investigational神经氨酸酶抑制剂以外的流感病毒抑制剂:聚焦血凝素靶点
Li-Yan Zeng,Jie Yang,Shuwen Liu
Li-Yan Zeng
Seasonal influenza and pandemic outbreaks typically result in high mortality and morbidity associated with severe economic burdens. Vaccines and anti-influenza drugs have made great contributions to control the infection. However, antigenic...
Denis Ciato,Aizhar G Mumbach,Marcelo Paez-Pereda et al.
Denis Ciato et al.
Cushing's disease (CD) is caused by a corticotroph adenoma of the pituitary gland that secretes excess adrenocorticotropic hormone (ACTH) causing increased morbidity and mortality. Surgery is the treatment of choice, but is not always succe...
Investigational serine/threonine kinase inhibitors against prostate cancer metastases [0.03%]
针对前列腺癌转移的丝氨酸/苏氨酸激酶抑制剂研究
Claudio Festuccia
Claudio Festuccia
Androgen deprivation therapy (ADT) is used as first therapeutic approach in prostate cancer (PCa) although castration resistant disease (CRPC) develops with high frequency. CRPC is the consequence of lack of apoptotic responses to ADT. Alte...
Daniela Galimberti,Elio Scarpini
Daniela Galimberti
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Pharmacological treatment of AD includes Anticholinesterase Inhibitors (AChEIs) for mild-moderate AD, and memantine for severe AD. These drugs provide mainly symp...