Strontium ranelate, a promising disease modifying osteoarthritis drug [0.03%]
具有改変骨关节炎病程作用的新型药物硫酸锶(ranelate)
Weiyu Han,Shicai Fan,Xiaochun Bai et al.
Weiyu Han et al.
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balanc...
Early investigational antibiotics for the treatment of acute exacerbations of chronic bronchitis [0.03%]
用于慢性支气管炎急性加重的试验性抗生素疗法
Matthew E Falagas,Maria Georgiou
Matthew E Falagas
Acute exacerbations in patients with chronic bronchitis are a leading cause of hospitalizations and death. Bacteria contribute significantly to such exacerbations. The aim of this review was to explore the potential role of investigational ...
Giuseppe Santini,Nadia Mores,Mario Malerba et al.
Giuseppe Santini et al.
Dupilumab (REGN668/SAR231893), produced by a collaboration between Regeneron and Sanofi, is a monoclonal antibody currently in phase III for moderate-to-severe asthma. Dupilumab is directed against the α-subunit of the interleukin (IL)-4 r...
Matilde Capi,Fernando de Andrés,Luana Lionetto et al.
Matilde Capi et al.
Migraine is one of the most common diseases in the world, with high economical and subjective burden. Migraine acute therapy is nowadays based on specific and non-specific drugs but up to 40% of episodic migraineurs still have unmet treatme...
Peter Penson,Mary McGowan,Maciej Banach
Peter Penson
Despite the effectiveness of statins in the treatment of lipid disorders, residual risk still exists, and hitherto studies where additional drugs were added to statin therapy have been mainly negative or the outcomes were very modest. There...
Olgun Elicin,Mahmut Ozsahin
Olgun Elicin
Cindy Strehl,Marlies C van der Goes,Johannes W J Bijlsma et al.
Cindy Strehl et al.
The beneficial effects of glucocorticoids are highly regarded in the treatment of inflammatory diseases. In rheumatoid arthritis, these drugs are widely used because they effectively reduce signs and symptoms of the disease, and exert disea...
Current treatment options and investigational drugs for Waldenstrom's Macroglobulinemia [0.03%]
瓦登氏肿瘤的当前治疗选择和研究性药物
Maria Gavriatopoulou,Evangelos Terpos,Efstathios Kastritis et al.
Maria Gavriatopoulou et al.
Waldenström's Macroglobulinemia (WM) is a rare, indolent, incurable, low-grade B-cell lymphoplasmacytic neoplasm. This review article provides a modern clinical perspective of the individualized management of patients with symptomatic WM, ...
The potential utility of tildrakizumab: an interleukin-23 inhibitor for the treatment of psoriasis [0.03%]
托利珠单抗的潜在疗效：一种治疗银屑病的白细胞介素-23抑制剂
Zenas Z N Yiu,Richard B Warren
Zenas Z N Yiu
The approved biologic therapies are effective for the treatment of psoriasis, but have limitations. Tildrakizumab has a different mechanism of action and is a humanized immunoglobulin G1κ that binds to the p19 subunit of IL23. Areas covere...