Yevher Lorena Barrón-Hernández,Antonella Tosti
Yevher Lorena Barrón-Hernández
Alopecia is a common condition observed among people of all ages. It is a disorder that can involve only the scalp as observed in androgenetic alopecia or scalp and body as in alopecia areata or patients under chemotherapy treatment. There ...
Eribulin in non-small cell lung cancer: challenges and potential strategies [0.03%]
艾日布林在非小细胞肺癌中的应用：挑战与潜在策略
Umang Swami,Umang Shah,Sanjay Goel
Umang Swami
Eribulin is a non-taxane, macrocyclic, synthetic, ketone analog of halichondrin B with a microtubule inhibitory action specific toward plus ends. It is approved by United States Food and Drug Administration (USFDA) for the treatment of pati...
Michelle A Levy,David F Claxton
Michelle A Levy
BCL-2 proteins are key players in the balance of cell life and death. Their roles in the development and biology of cancer have been well established and continue to be investigated. Understanding the mechanisms by which these proteins regu...
Peter A Ricketti,Sultan Alandijani,Chen Hsing Lin et al.
Peter A Ricketti et al.
Allergic rhinitis (AR) is a multifactorial disease characterized by paroxysmal symptoms of sneezing, rhinorrhea, postnasal drip and nasal congestion. For over a century, subcutaneous allergen immunotherapy (SCIT) has been recognized as the ...
Siltuximab and hematologic malignancies. A focus in non Hodgkin lymphoma [0.03%]
西妥珠单抗与血液系统恶性肿瘤的研究进展——以非霍奇金淋巴瘤为例
Andrea Ferrario,Michele Merli,Claudia Basilico et al.
Andrea Ferrario et al.
The role of interleukin-6 (IL-6) in tumorigenesis and in particular in haematological malignancies is crucial. On the basis of the favourable results obtained in the subset of multicentric Castleman disease (MCD), Siltuximab, a chimeric, hu...
Gareth J Sanger,Pankaj Jay Pasricha
Gareth J Sanger
Gastroparesis is defined by nausea, vomiting, pain, early satiety and bloating, and characterized by delayed gastric emptying without obvious structural abnormalities. Metoclopramide is widely used, increasing gastric emptying and inhibitin...
Antonella De Luca,Daniela Frezzetti,Marianna Gallo et al.
Antonella De Luca et al.
Breast cancer is a complex disease and several molecular drivers regulate its progression. Fibroblast growth factor receptor (FGFR) signaling is frequently deregulated in many cancers, including breast cancer. Due the involvement of the FGF...
Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease [0.03%]
用于慢性阻塞性肺病治疗的研究β-2肾上腺素受体激动剂
Mario Malerba,Alessandro Radaeli,Paolo Montuschi et al.
Mario Malerba et al.
Long-acting bronchodilators are pivotal in the therapeutic management of COPD patients with moderate-to-severe airflow obstruction. New ultra-long-acting β2-agnoists (ultra-LABAs) have been developed, some of which have been licensed for u...
Corrigendum [0.03%]
勘误表
Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development [0.03%]
靶向5-羟色胺受体的偏头痛治疗药物研发：I期和II期临床在研药物概览
Piero Barbanti,C Aurilia,G Egeo et al.
Piero Barbanti et al.
Research has focused on serotonin (5-HT) 5-HT1D and 5-HT1F receptors to develop drugs acting through non-vasoconstrictive mechanisms for treating acute migraine and those targeting 5-HT2B and 5-HT7 receptors for preventing migraine. Areas c...