Francesco Caso,Luisa Costa,Matteo Megna et al.
Francesco Caso et al.
Introduction: Psoriatic arthritis (PsA) is a chronic immunoinflammatory disease of the enthesis and adjacent synovium, skin, and nail, which early diagnosis may be crucial for starting a prompt therapeutic intervention. T...
Developing targeted therapeutics for hepatocellular carcinoma: a critical assessment of promising phase II agents [0.03%]
肝细胞癌靶向治疗药物的研发：颇具前景的二期药物的关键性评估
Elisabeth Amadeo,Silvia Foti,Silvia Camera et al.
Elisabeth Amadeo et al.
Introduction: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the first for primary liver tumors. In recent years greater therapeutic advancement was represented by employment of tyrosine kina...
Safety, tolerability and pharmacokinetics of ASC10, a novel oral double prodrug of a broad-spectrum antiviral agent, β-d-N4-hydroxycytidine: results from a randomized, double-blind, placebo-controlled phase 1 study in Chinese healthy subjects [0.03%]
ASC10，一种广谱抗病毒药物β-D-N4-羟基胞苷双前药的新型口服制剂，在中国健康志愿者中的I期随机、双盲和安慰剂对照研究结果：安全性、耐受性和药代动力学
Jian Liu,Qingwei Zhao,You Zhai et al.
Jian Liu et al.
Background: Considering the rise of new SARS-CoV-2 variants that have reduced the efficacy of COVID-19 vaccines, the development of new antiviral medications for the disease has become increasingly necessary. In this stud...
Investigational and emerging gastric inhibitory polypeptide (GIP) receptor-based therapies for the treatment of obesity [0.03%]
胃抑制多肽(GIP)受体为基础的肥胖症治疗药物的研究与进展
Robert H Gaffey,Afua K Takyi,Alpana Shukla
Robert H Gaffey
Introduction: One billion people live with obesity. The most promising medications for its treatment are incretin-based therapies, based on enteroendocrine peptides released in response to oral nutrients, specifically glu...
Emerging treatment landscape for Guillain-Barré Syndrome (GBS): what's new? [0.03%]
Guillain-Barré综合征（GBS）的新兴治疗格局：有什么新进展？
Alina Sprenger-Svačina,Martin K R Svačina,Tong Gao et al.
Alina Sprenger-Svačina et al.
Introduction: Guillain-Barré syndrome (GBS) is a monophasic immune neuropathic disorder characterized by acute paralysis. A significant portion of patients are left with residual deficits, which presents a considerable g...
Medical treatments for abdominal aortic aneurysm: an overview of clinical trials [0.03%]
腹主动脉瘤的治疗方法：临床试验概论
Jinyi Chen,Lanting Hu,Zhenjie Liu
Jinyi Chen
Introduction: Abdominal aortic aneurysm is a progressive, segmental, abdominal aortic dilation associated with a high mortality rate. Abdominal aortic aneurysms with diameters larger than 55 mm are associated with a high ...
New investigational drugs for steroid-refractory acute graft-versus-host disease: a review of the literature [0.03%]
难治性急性移植物抗宿主病新药临床前及临床研究进展：文献综述
Na Hyun Kim,Mehdi Hamadani,Sameem Abedin
Na Hyun Kim
Introduction: Steroid-refractory acute graft-versus-host disease (SR-aGVHD) remains a formidable obstacle in the field of allogeneic hematopoietic cell transplantation (allo-HCT), significantly contributing to patient mor...
An overview of the safety and efficacy of LX-9211 in treating neuropathic pain conditions [0.03%]
LX-9211治疗神经病理性疼痛的安全性和有效性的综述
William C Upshaw,John M Richey,Gurjot Ravi et al.
William C Upshaw et al.
Introduction: LX-9211 is a drug designed to treat neuropathic pain conditions. It functions by inhibiting the adaptor-associated kinase 1 (AAK1) enzyme which promotes clathrin-dependent endocytosis. Preclinical studies ha...
Rheumatoid arthritis extra-articular lung disease: new insights on pathogenesis and experimental drugs [0.03%]
类风湿关节炎肺外疾病：发病机制和实验性药物的新见解
Marco Sebastiani,Andreina Manfredi,Stefania Croci et al.
Marco Sebastiani et al.
Introduction: Pulmonary involvement is one of the most common extra-articular manifestations of rheumatoid arthritis (RA), a systemic inflammatory disease characterized by joint swelling and tenderness. All lung compartme...
Trastuzumab-deruxtecan in solid tumors with HER2 alterations: from early phase development to the first agnostic approval of an antibody-drug conjugate [0.03%]
针对HER2异常的实体瘤中曲妥珠单抗杜克勒生：从早期临床开发到首个抗体药物偶联物的获批
Crimini Edoardo,Curigliano Giuseppe
Crimini Edoardo
Introduction: Antibody-drug conjugates (ADCs) represent a revolutionary approach in the systemic treatment for both solid and hematologic tumors. Constituted by an antibody, a cytotoxic payload, and a linker, ADCs aim to ...