Pharmacotherapeutic potentials of astragalin against cisplatin-induced renal toxicity via regulating Nrf-2/keap-1 pathway [0.03%]
astragalin通过调节Nrf-2/Keap-1通路对抗顺铂引起的肾毒性的药理治疗潜力
Muhammad Umar Ijaz,Rubab Furqan,Muhammad Zaid Salar et al.
Muhammad Umar Ijaz et al.
Purpose: Cisplatin (CP) is a chemotherapeutic drug that can produce toxic effects in many organs of the body including kidney. Thus, the current trial was executed for 30 days to assess the alleviative effects of AST to a...
Zhenwu Bian,Liu Wei
Zhenwu Bian
Context: Coenzyme Q10 (CoQ10) is a vital compound found in nearly all cells, and in mitochondria, it facilitates ATP production, and its reduced form acts as a powerful antioxidant, neutralizing reactive oxygen species (ROS) and preventing ...
Evaluation of leptin and leptin receptor gene polymorphisms in bipolar disorder: focus on depressive episodes with atypical features [0.03%]
双相障碍中瘦素和瘦素受体基因多态性的评价：以非典型特征的抑郁发作为重点研究对象
Hasan Mervan Aytac,Yasemin Oyaci,Eren Aytac et al.
Hasan Mervan Aytac et al.
Objective: Our study aims to examine the effect of leptin (LEP) (-2548 G > A) (rs7799039) and leptin receptor (LEPR) (668 A > G) (rs1137101) gene polymorphisms on the etiopathogenesis of bipolar disorder (BD) by comparing them with a contro...
The impact of a multi-species probiotic supplementation on clinical symptoms and biochemical factors in patients with irritable bowel syndrome: a randomised controlled trial [0.03%]
一项关于益生菌补充剂对肠易激综合症患者临床症状及生化因素影响的随机对照试验
Shirin Hajiani,Maryam Tajabadi Ebrahimi,Amir Sadeghi et al.
Shirin Hajiani et al.
Background: Intestinal inflammation and oxidative stress contribute to the pathophysiology of irritable bowel syndrome (IBS). This clinical trial investigated the effects of a probiotic supplementation on symptom severity and quality of lif...
Heptaminol-induced metabolic liver and cardiac injuries in rats: phytochemical screening, experimental, computational modelling and pharmacological study of phoenix dactylifera seeds [0.03%]
-heptaminol诱导的大鼠代谢性肝和心脏损伤：Phoenix dactylifera种子的植物化学筛选、实验、计算模型和药理学研究
Raoudha Abbassi,Hafsia Bouzenna,Riadh Badraoui et al.
Raoudha Abbassi et al.
Introduction: Heptaminol (HEP) is widely used and characterized by liver and cardiac risk factors, dysregulated prooxidant-antioxidant balance, and inflammation. This study aimed to study the phytochemical composition of date seeds of Phoen...
Comparable hepatocellular metabolomic signatures under glucose and palmitic acid treatment relative to butyrate in relation to metabolic dysfunction-associated fatty liver disease [0.03%]
与丁酸相比葡萄糖和棕榈酸处理下与代谢紊乱相关脂肪肝疾病的肝细胞代谢标志物的比较
Nehal;Jyoti;Priyankar Dey
Nehal;Jyoti;Priyankar Dey
Introduction: Among the dietary factors, glucose, and fatty acids are known to trigger fatty liver disease, while butyrate attenuates steatosis. Objective...
Selenium deficiency modulates neonatal pulmonary alveolar development via mitochondrial ROS accumulation and oxidative stress mediated by STAT3 inhibition [0.03%]
硒缺乏通过STAT3抑制介导的线粒体ROS积累和氧化应激调制新生肺泡发育
Hong-Yan Tan,Yao-Lin Xiang,Mei-Juan Tan et al.
Hong-Yan Tan et al.
Context: Recent findings suggest that Selenium (Se) deficiency in neonates may hinder pulmonary alveolar development, but the underlying molecular mechanisms remain underexplored. Objective: This study utilised a neonat...
Evaluation of Annona muricata for hepatoprotection, hematological assessment and inhibitor of TGFβR1 in liver diseases [0.03%]
评价番木瓜对肝脏保护、血液学评估及肝病TGFβR1抑制剂的作用
Zacchaeus S Ololade,Iyadunni A Anuoluwa,Olayinka F Onifade et al.
Zacchaeus S Ololade et al.
Background: This study was conducted to assess the hepatoprotective potential of Annona muricata flower (AMF) using albino rats' model. Materials and meth...
Cholecalciferol alleviates testicular dysfunction in experimental hyperthyroidism via antioxidant, anti-inflammatory and antiapoptotic effects [0.03%]
胆钙化醇通过抗氧化、抗炎和抗凋亡作用缓解实验性甲状腺功能亢进引起的睾丸功能障碍
Heba Rady Salem,Hend Ahmed Kasem
Heba Rady Salem
Background: This study aimed to investigate the possible protective effect of cholecalciferol against testicular dysfunction in L-thyroxine-induced hyperthyroid rat model. ...