Colorectal cancer:the immune microenvironment and the gut microbiota - new perspectives, challenges, and opportunities [0.03%]
结直肠癌：免疫微环境与肠道微生物群——新视角、挑战和机遇
Ping Zhou,Wangzheqi Zhang,Yan Liao et al.
Ping Zhou et al.
Abstract: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and poses significant clinical challenges. In the context of multi-omics advancements, the intricate relationships between the gut microbiot...
Ex vivo machine perfusion of extended-criteria donor livers a Bayesian network meta-analysis [0.03%]
基于扩展供肝条件的离体机器灌注的贝叶斯网络meta分析研究
Minseok Kang,Nguyen Thi Huyen Trang,Seonju Kim et al.
Minseok Kang et al.
Background: Ex vivo liver perfusion offers benefits over static cold storage (SCS) for organ preservation, but specific advantages of different perfusion protocols require further evaluation. ...
Prolonged recurrence-free survival by autologous rectronectin-activated killer (RAK) cells in resected high-risk hepatocellular carcinoma: an experimental single-arm Phase II trial (pilot study) [0.03%]
自体回肠门静脉引流激活的杀伤细胞治疗切除高危肝癌患者的长期无复发生存：一项实验性单臂二期临床试验（试点研究）
Yiran Wang,Jing Xu,Luyao Zhang et al.
Yiran Wang et al.
Background: Hepatocellular carcinoma (HCC) is prone to recurrence following hepatectomy, posing significant clinical challenges. Our previous research suggested that adoptive T-cell therapy could improve the impaired live...
Clinical trends and platform-antigen synergy in glioblastoma vaccine development: a Trialtrove-based analysis [0.03%]
基于Trialtrove的分析在胶质母细胞瘤疫苗开发中的平台抗原协同作用和临床趋势
Jiajie Yuan,Shenglin Chen,Jun Liu et al.
Jiajie Yuan et al.
Burden disparities of genitourinary diseases among adults aged 55 and older in europe: trends From 1990 to 2021 and projections to 2030 a Cross-sectional Study [0.03%]
欧洲55岁及以上成人泌尿生殖系统疾病负担差异：1990年至2021年趋势及2030年预测横断面研究
Zhiyong Zhang,Yuanchao Zhu,Fenjin Zhao et al.
Zhiyong Zhang et al.
Background: Genitourinary diseases significantly affect the quality of life of elderly individuals in Europe, yet comprehensive studies on their burden remain limited. This study used Global Burden of Disease (GBD) 2021 d...
New perspectives on the potential mechanisms, prevention and treatment of deep vein thrombosis complicated by lung cancer [0.03%]
肺癌合并深静脉血栓新观点及其机制、预防和治疗
Wenlong Zhang,Siqing Yue,Hui Fang et al.
Wenlong Zhang et al.
The prevalence of lung cancer has increased significantly in recent years. This malignancy is the most lethal form of tumor and exhibits the highest morbidity and mortality rates among all malignant tumors. Venous thromboembolism (VTE) incl...
Tertiary lymphoid structures signature predicts prognosis and clinical benefits from adjuvant chemotherapy and PD-L1 blockade in colorectal adenocarcinoma [0.03%]
三级淋巴器官结构特征可预测结直肠腺癌辅助化疗和PD-L1阻断的临床获益及预后
Zichao Guo,Haoran Feng,Wenqing Jia et al.
Zichao Guo et al.
Background: Tertiary lymphoid structures (TLS) are emerging biomarkers for enhanced anti-tumoral immunity and treatment efficacy in colorectal cancer (CRC). This study aimed to develop a CRC-specific TLS signature and eva...
Re-exploration of the optimal threshold for restrictive transfusion after hip fracture: a multicenter prospective Cohort [0.03%]
髋关节骨折后限制性输血最佳阈值的重新探索：一项多中心前瞻性队列研究
Dajun Jiang,Mao Wei,Sen Lin et al.
Dajun Jiang et al.
Background: Restrictive transfusion is recommended in patients undergoing hip fracture surgery. However, the evidence regarding the optimal threshold for transfusion remained uncertain. ...
Evaluating generative AI models for explainable pathological feature extraction in lung adenocarcinoma grading assessment and prognostic model construction [0.03%]
评估生成式AI模型在肺癌腺癌分级评估和预后模型构建中的解释性病理特征提取能力
Junyi Shen,Suyin Feng,Pengpeng Zhang et al.
Junyi Shen et al.
Background: Given the increasing prevalence of generative AI (GenAI) models, a systematically evaluation of their performance in lung adenocarcinoma histopathological assessment is crucial. This study aimed to evaluate an...