Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content [0.03%]
不同不饱和脂肪酸含量的混合脂质配方调节果糖/蔗糖致肝脂肪变性的比较研究
Rafat A Siddiqui,Zhidong Xu,Kevin A Harvey et al.
Rafat A Siddiqui et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. NAFLD encompasses a spectrum of diseases, ranging from hepatic steatosis to non-alcoholic ste...
FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity [0.03%]
母体肥胖诱导子代肾脏糖脂代谢紊乱与 FXR 表达有关
Sarah J Glastras,Muh Geot Wong,Hui Chen et al.
Sarah J Glastras et al.
Background: Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is recognized that maternal obesity predisposes offsp...
Ghrelin, adipokines, metabolic factors in relation with weight status in school-children and results of a 1-year lifestyle intervention program [0.03%]
生长激素释放肽、脂肪细胞因子及代谢因素与学龄儿童体重状态的关系以及生活方式干预结果的1年随访调查研究
Christine Rambhojan,Elodie Bouaziz-Amar,Laurent Larifla et al.
Christine Rambhojan et al.
Background: Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weig...
Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study [0.03%]
在《动脉粥样硬化遗传学（GEA）研究》中，饮食脂肪和碳水化合物调节ATP结合 cassette A1（ABCA1）R230C变异体对经前期女性代谢危险因素的影响
Leonor Jacobo-Albavera,Carlos Posadas-Romero,Gilberto Vargas-Alarcón et al.
Leonor Jacobo-Albavera et al.
Background: Although the R230C-ATP-binding cassette A1 (ABCA1) variant has been consistently associated with HDL-C levels, its association with diabetes and other metabolic parameters is unclear. Estrogen and dietary fact...
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice [0.03%]
短期高脂饮食加速小鼠肌肉特异性的失用性萎缩和蛋白质降解
Steven L Roseno,Patrick R Davis,Lance M Bollinger et al.
Steven L Roseno et al.
Background: A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals...
Low-calcium diet prevents fructose-induced hyperinsulinemia and ameliorates the response to glucose load in rats [0.03%]
低钙饮食可预防果糖致大鼠胰岛素抵抗并改善葡萄糖耐量反应
Anna Voznesenskaya,Michael G Tordoff
Anna Voznesenskaya
Background: Consuming a fructose-rich diet leads to hyperinsulinemia, impaired glucose tolerance, and insulin resistance. In humans, the consumption of high levels of refined sugars often coincides with a diet containing ...
Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure [0.03%]
与脂肪酸和葡萄糖代谢相关的脂肪组织蛋白在体重减轻过程中发生的变化与能量消耗的适应有关
Stefan G J A Camps,Sanne P M Verhoef,Nadia Roumans et al.
Stefan G J A Camps et al.
Background: Energy restriction causes adaptations in energy expenditure (total-,TEE; resting-,REE; activity induced-,AEE). Objective: T...
A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes [0.03%]
随机对照试验：低聚果糖对前驱糖尿病患者体重管理和异位脂肪的影响
Nicola D Guess,Anne Dornhorst,Nick Oliver et al.
Nicola D Guess et al.
Background: Fat infiltration of the liver, muscle and pancreas is associated with insulin resistance and risk of diabetes. Weight loss reduces ectopic fat deposition and risk of diabetes, but is difficult to sustain to du...
Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised [0.03%]
肝S1P缺乏在LDLR功能受损时可降低载脂蛋白B含脂蛋白的血浆胆固醇水平
Debapriya Basu,Afroza Huq,Jahangir Iqbal et al.
Debapriya Basu et al.
Background: Site-1 protease (S1P) is the key enzyme required for activation of the sterol regulatory element binding proteins (SREBPs) that govern lipid synthesis. While S1P has been speculated to influence plasma apoB-co...
Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy [0.03%]
中度限食使肥胖小鼠恢复至正常体重可逆转β细胞功能障碍：自噬的介导作用
Xiuying Gao,Dien Yan,Yinan Zhao et al.
Xiuying Gao et al.
Background: Severe calorie restriction (CR) is shown to improve or even reverse β-cell dysfunction in patients with obesity and type 2 diabetes mellitus. However, whether mild to moderate CR can reverse β-cell dysfuncti...