The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice [0.03%]
胆固醇酯转移蛋白对小鼠胰岛β细胞功能障碍的影响
Wen Guo,Yingyun Gong,Zhenzhen Fu et al.
Wen Guo et al.
Background: Cholesterol accumulation causes pancreatic beta cell lipotoxicity and dysfunction. Cholesteryl ester transfer protein (CETP) plays an important role in blood lipid homeostasis. However, its role in tissue lipi...
Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism [0.03%]
胰岛素或葡萄糖负荷后瘦素处理大鼠血糖的改善与肝脏糖代谢有关
Emma Burgos-Ramos,Sandra Canelles,Laura M Frago et al.
Emma Burgos-Ramos et al.
Background: Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulin's hepatic actions. Since central leptin may modify insulin signaling in the liver, ...
Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats [0.03%]
高碳水化合物再进食饮食的体重恢复促进厌食症大鼠快速体重回升和肝脏脂质积累
Erin D Giles,Jennifer Hagman,Zhaoxing Pan et al.
Erin D Giles et al.
Background: There is currently no standard clinical refeeding diet for the treatment of anorexia nervosa (AN). To provide the most efficacious AN clinical care, it is necessary to define the metabolic effects of current r...
Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver [0.03%]
短链酰基辅酶a脱氢酶缺乏和短期高脂饮食通过干扰肝脏线粒体能量代谢及脂肪处理的转录调控而损害肝脏功能
Sujoy Ghosh,Claudia Kruger,Shawna Wicks et al.
Sujoy Ghosh et al.
Background: The liver is an important site of fat oxidation, which participates in the metabolic regulation of food intake. We showed previously that mice with genetically inactivated Acads, encoding short-chain acyl-CoA ...
The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells [0.03%]
脂滴形成对保护胰岛素分泌细胞抵抗棕榈酸诱导的脂毒性的作用研究
Thomas Plötz,Magnus Hartmann,Sigurd Lenzen et al.
Thomas Plötz et al.
Background: Type 2 diabetes is associated with increased plasma concentrations of non-esterified fatty acids (NEFAs), which trigger pancreatic β-cell dysfunction and apoptosis. Only long-chain saturated NEFAs induced lip...
High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications [0.03%]
高果糖和高脂肪饮食诱导的大鼠紊乱：对糖尿病风险以及肝血管并发症的影响
Iona Lozano,Remmelt Van der Werf,William Bietiger et al.
Iona Lozano et al.
Background: As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particula...
Nazarii Kobyliak,Caterina Conte,Giovanni Cammarota et al.
Nazarii Kobyliak et al.
The worldwide prevalence of obesity more than doubled between 1980 and 2014. The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperature that have paralleled the soc...
Metabolism and bioavailability of newly developed dietary fiber materials, resistant glucan and hydrogenated resistant glucan, in rats and humans [0.03%]
新型膳食纤维抗性谷兰和氢化抗性谷兰的代谢及人体利用状况研究
Sadako Nakamura,Kenichi Tanabe,Shigeki Morita et al.
Sadako Nakamura et al.
Background: Resistant glucan (RG) and hydrogenated resistant glucan (HRG) are new dietary fiber materials developed to decrease the risk of metabolic syndrome and lifestyle-related diseases. We investigated the metabolism...
Alterations in protein and amino acid metabolism in rats fed a branched-chain amino acid- or leucine-enriched diet during postprandial and postabsorptive states [0.03%]
喂食分支氨基酸或亮氨酸强化饮食的大鼠在餐后和空腹状态下的蛋白质及氨基酸代谢变化
Milan Holecek,Pavel Siman,Melita Vodenicarovova et al.
Milan Holecek et al.
Background: Many people believe in favourable effects of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), especially leucine, on muscle protein balance and consume BCAAs for many years. We determined t...
Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial [0.03%]
多种维生素和矿物质对认知任务执行期间的全身能量代谢和脑血流的调节作用：一项双盲随机对照试验
David O Kennedy,Emma J Stevenson,Philippa A Jackson et al.
David O Kennedy et al.
Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity. Both energy metabolism and cerebral vaso-dilation...