Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration [0.03%]
镰状细胞病的致病因素及靶向治疗——特殊营养素的考虑因素
Shahida A Khan,Ghazi Damanhouri,Ashraf Ali et al.
Shahida A Khan et al.
Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choi...
Xunxian Liu,Zemin Yao
Xunxian Liu
Loss of cellular response to hormonal regulation in maintaining metabolic homeostasis is common in the process of aging. Chronic over-nutrition may render cells insensitive to such a hormonal regulation owing to overstimulation of certain s...
Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane [0.03%]
饮食脂质暴露导致细胞质脂滴在刷状缘膜附近快速产生
Zeina Soayfane,François Tercé,Michela Cantiello et al.
Zeina Soayfane et al.
Background: Intestinal absorption of dietary lipids involves their hydrolysis in the lumen of proximal intestine as well as uptake, intracellular transport and re-assembly of hydrolyzed lipids in enterocytes, leading to t...
The ghrelin and leptin responses to short-term starvation vs a carbohydrate-free diet in men with type 2 diabetes; a controlled, cross-over design study [0.03%]
短期饥饿与无碳水化合物饮食对2型糖尿病男性胃抑素和瘦素的影响：一种交叉对照设计研究
Frank Quentin Nuttall,Rami Mahmoud Almokayyad,Mary Carol Gannon
Frank Quentin Nuttall
Background: We recently have reported the 24-hour glucose, insulin and glucagon responses to a 72-hour fast compared to a 72-hour macronutrient-sufficient, carbohydrate-free diet in men with type 2 diabetes. The 72-hour t...
Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men [0.03%]
高脂饮食过度摄入致肝脏脂肪蓄积：南亚男性和高加索男性的对比研究
Siti N Wulan,Vera B Schrauwen-Hinderling,Klaas R Westerterp et al.
Siti N Wulan et al.
Background: South Asians were reported to have a higher liver fat content as compared to BMI-matched Caucasians. This study compared the increase in liver fat content in response to overfeeding with a high fat diet in Sou...
Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia [0.03%]
Slc30a8/ZnT8在小鼠α细胞中的过度表达损害了胰高血糖素的释放以及对低血糖的反应能力
Antonia Solomou,Erwann Philippe,Pauline Chabosseau et al.
Antonia Solomou et al.
Background: The human SLC30A8 gene encodes the secretory granule-localised zinc transporter ZnT8 whose expression is chiefly restricted to the endocrine pancreas. Single nucleotide polymorphisms (SNPs) in the human SLC30A...
Recombinant human growth hormone and insulin-like growth factor-1 do not affect mitochondrial derived highly reactive oxygen species production in peripheral blood mononuclear cells under conditions of substrate saturation in-vitro [0.03%]
体外底物饱和条件下，重组人生长激素和胰岛素样生长因子-1不会影响外周血单个核细胞中由线粒体衍生的高反应性氧生成物种产生
James Keane,Lotti Tajouri,Bon Gray
James Keane
Background: The purpose of this study was to investigate the mitochondrial effects exerted by physiological and supra-physiological concentrations of recombinant human growth hormone (rhGH) and recombinant insulin-like gr...
Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory [0.03%]
白藜芦醇可改善胰岛素治疗糖尿病大鼠的血糖控制：肝脏区域的作用
Caio Yogi Yonamine,Erika Pinheiro-Machado,Maria Luiza Michalani et al.
Caio Yogi Yonamine et al.
Background: Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which ...
Divergent pathway of lipid profile components for cardiovascular disease and mortality events: Results of over a decade follow-up among Iranian population [0.03%]
血脂成分与心血管疾病及死亡事件的分化途径：伊朗人群超过十年随访结果
Zahra Ghasemzadeh,Hengameh Abdi,Samaneh Asgari et al.
Zahra Ghasemzadeh et al.
Background: Data regarding the impact of different lipid measures on cardiovascular diseases (CVD) and mortality events is not consistent. We aimed to evaluate the relationship between different lipid parameters and incid...
Milk miRNAs: simple nutrients or systemic functional regulators? [0.03%]
牛奶中的miRNA：简单的营养物质还是系统的功能调节因子？
Bodo C Melnik,Foteini Kakulas,Donna T Geddes et al.
Bodo C Melnik et al.
Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are transferred to the offspring a...