Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial [0.03%]
非酒精性脂肪肝发生及逆转患者的血清代谢组改变——地中海饮食对非酒精性脂肪肝代谢物影响的靶向代谢组学研究
Christopher Papandreou,Mònica Bullò,Francisco José Tinahones et al.
Christopher Papandreou et al.
Background: Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in m...
Phenylketonuria patients' and their parents' knowledge and attitudes to the daily diet - multi-centre study [0.03%]
苯酮尿症患者及其父母对日常饮食的知识和态度-多中心研究
Ewa Witalis,Bozena Mikoluc,Radoslaw Motkowski et al.
Ewa Witalis et al.
Background: The aim of the study was to assess both patients' and their parents' knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet. ...
Recombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis [0.03%]
重组SFRP5蛋白可显著缓解非酒精性脂肪肝病的肝内炎症
Lili Chen,Xiaolong Zhao,Guangjun Liang et al.
Lili Chen et al.
Background: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatit...
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer [0.03%]
牛奶破坏基因守护者p53和DNMT1的机能：对痤疮与前列腺癌的意义
Bodo C Melnik
Bodo C Melnik
There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regula...
Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity [0.03%]
高脂餐对腹型2型糖尿病患者餐后血脂代谢的影响
Feng Wang,Huixia Lu,Fukang Liu et al.
Feng Wang et al.
Background: Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingest...
Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin [0.03%]
新诊断的代谢综合征患者血清锌-α2-糖蛋白水平低且与脂联素呈相关关系
Lu Lei,Kejia Li,Ling Li et al.
Lu Lei et al.
Background: Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investiga...
DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes [0.03%]
DHA比EPA更有效通过调节PPARγ及其Ser273磷酸化在相对低浓度增加3T3-L1脂肪细胞中脂联素表达
Jia Song,Cheng Li,Yushan Lv et al.
Jia Song et al.
Background: Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were rep...
Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: a randomized, crossover, controlled feeding trial [0.03%]
杏仁可改善中国2型糖尿病患者(尤其是血糖控制较好者)的血糖水平：随机交叉对照饮食试验
Chiao-Ming Chen,Jen-Fang Liu,Sing-Chung Li et al.
Chiao-Ming Chen et al.
Background: Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compare...
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet [0.03%]
eIF2α磷酸化可防止高果糖饮食小鼠肝细胞死亡和肝纤维化现象发生
Woo-Gyun Choi,Jaeseok Han,Ji-Hyeon Kim et al.
Woo-Gyun Choi et al.
Background: Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse ce...
Season and vitamin D status are independently associated with glucose homeostasis in pregnancy [0.03%]
季节和维生素D状况会独立影响妊娠期糖代谢
Eileen C O&#x;Brien,Elizabeth J O&#x;Sullivan,Mark T Kilbane et al.
Eileen C O&#x;Brien et al.
Background: Vitamin D status and season are intrinsically linked, and both have been proposed to be associated with glucose homeostasis in pregnancy, with conflicting results. We aimed to determine if exposure to winter a...