Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity [0.03%]
叶酸预防高脂饮食诱导的肥胖小鼠心室功能障碍和减少心肌纤维化
Wei Li,Renqiao Tang,Shengrong Ouyang et al.
Wei Li et al.
Background: Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and car...
Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats [0.03%]
高脂饮食可通过母系跨代损害后代糖代谢、胰岛β细胞功能和增殖能力
Yan-Hong Huang,Ting-Ting Ye,Chong-Xiao Liu et al.
Yan-Hong Huang et al.
Background: This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2). ...
Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine [0.03%]
小肠低脂和高脂餐后响应基因的主要转录调控因子鉴定
Octave Mucunguzi,Aicha Melouane,Abdelaziz Ghanemi et al.
Octave Mucunguzi et al.
Background: High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal muc...
Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat [0.03%]
餐后低度炎症无需特定激活大鼠TLR4
Dominique Hermier,Véronique Mathé,Annaïg Lan et al.
Dominique Hermier et al.
Background: Toll-like receptor 4 (TLR4), an innate immune receptor, is suspected to play a key role in the postprandial inflammation that is induced by a high-fat meal rich in saturated fatty acids (SFA). Our objective wa...
Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population [0.03%]
血清丙氨酸氨基转移酶/天门冬氨酸氨基转移酶比值为中国人群胰岛素抵抗的最佳标志物之一
Li Zhao,Jing Cheng,Yingchao Chen et al.
Li Zhao et al.
Background: The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio an...
Markers of neuroprotection of combined EPA and DHA provided by fish oil are higher than those of EPA (Nannochloropsis) and DHA (Schizochytrium) from microalgae oils in Wistar rats [0.03%]
与微藻油中的EPA（纳诺齐藻）和DHA（裂头孢藻）相比，鱼油中EPA和DHA组合的神经保护标志物在Wistar大鼠中的含量更高
Paula A Lopes,Narcisa M Bandarra,Susana V Martins et al.
Paula A Lopes et al.
Background: To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eic...
Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women [0.03%]
FGF21与2型糖尿病的性别差异关联：新加坡华人队列中的病例对照研究
Yeli Wang,Woon-Puay Koh,Jian-Min Yuan et al.
Yeli Wang et al.
Background: Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between ...
Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial [0.03%]
植物固醇、红曲米或两者短期膳食补充对中度高胆固醇血症患者的血脂影响：一项三组、双盲随机临床试验
Arrigo F G Cicero,Federica Fogacci,Martina Rosticci et al.
Arrigo F G Cicero et al.
Background: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid...
Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis [0.03%]
白藜在2型糖尿病患者血糖控制及胰岛素敏感性中的作用：系统综述和meta分析
Xiangyun Zhu,Chunhua Wu,Shanhu Qiu et al.
Xiangyun Zhu et al.
Although the regular consumption of resveratrol has been known to improve glucose homeostasis and reverse insulin resistance in type 2 diabetes mellitus (T2DM), the reported results are inconsistent. Thus, we aimed to assess the effects of ...
Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats [0.03%]
支链氨基酸补充剂可通过迷走神经恢复低蛋白饮食造成的胰岛素促分泌作用减退（英文）
Mami Horiuchi,Tomoya Takeda,Hiroyuki Takanashi et al.
Mami Horiuchi et al.
Background: Previously, we reported that a low-protein diet significantly reduced insulin secretion in response to feeding within 1 h in rats, suggesting that the insulinotropic effect of dietary protein plays an importan...