Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity [0.03%]
姜黄素通过调节肝脏PI3K-AKT轴和IDE以及胰岛的完整性来增强饮食诱导肥胖小鼠胰岛素清除率
Yoo Kim,Michael Rouse,Isabel González-Mariscal et al.
Yoo Kim et al.
Background: Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction sig...
Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers [0.03%]
黄酮类化合物诱导白色脂肪组织褐变和产热：信号通路与分子触发因素
Xuejun Zhang,Xin Li,Huang Fang et al.
Xuejun Zhang et al.
Background: Flavonoids are a class of plant and fungus secondary metabolites and are the most common group of polyphenolic compounds in the human diet. In recent studies, flavonoids have been shown to induce browning of w...
Postprandial glycemic response in a non-diabetic adult population: the effect of nutrients is different between men and women [0.03%]
非糖尿病成人餐后血糖反应的性别差异及其影响因素
María González-Rodríguez,Marcos Pazos-Couselo,José M García-López et al.
María González-Rodríguez et al.
Background: There is a growing interest in the pathopysiological consequences of postprandial hyperglycemia. It is well known that in diabetic patients 2 h plasma glucose is a better risk predictor for coronary heart dise...
Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism [0.03%]
连续摄入海藻糖可诱导白色脂肪组织褐变并增强能量代谢
Chikako Arai,Norie Arai,Shigeyuki Arai et al.
Chikako Arai et al.
Background: Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new...
Visceral fat reduction is positively associated with blood pressure reduction in overweight or obese males but not females: an observational study [0.03%]
腹部脂肪减少与男性而非女性血压降低呈正相关：一项观察性研究
Xiaohui Guo,Yifan Xu,Hairong He et al.
Xiaohui Guo et al.
Background: Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between viscer...
Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure [0.03%]
Ccr7基因敲除小鼠通过上调UCP1和增强能量消耗抵抗高脂饮食诱导的肥胖
Tomomi Sano,Taiki Sanada,Yusuke Sotomaru et al.
Tomomi Sano et al.
Background: The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resist...
Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB [0.03%]
白藜芦醇通过激活转录因子EB诱导自噬从而减轻内皮细胞氧化损伤
Xi Zhou,Jining Yang,Min Zhou et al.
Xi Zhou et al.
Background: Endothelial oxidative injury is a key event in the pathogenesis of atherosclerosis (AS). Resveratrol (RSV) attenuates the oxidative injury in human umbilical vein endothelial cells (HUVECs). Autophagy is criti...
Zhenguo Wang,Lu Wang,Zhuzhen Zhang et al.
Zhenguo Wang et al.
Background: Apolipoprotein A-IV (ApoA-IV) exists in relatively high levels in the circulation systems of animals, but its roles are not fully elucidated. It is known that the Apoa4 gene resides in the cluster Apoa1/Apoc3/...
Caprylic acid suppresses inflammation via TLR4/NF-κB signaling and improves atherosclerosis in ApoE-deficient mice [0.03%]
辛酸通过TLR4/NF-κB信号通路抑制炎症并改善ApoE基因缺陷小鼠的动脉粥样硬化病情
Xinsheng Zhang,Changyong Xue,Qing Xu et al.
Xinsheng Zhang et al.
Background: As reported previously by our group, medium-chain triglycerides can ameliorate atherosclerosis. Given that TLR4 is closely related to atherosclerosis, we hypothesized herein that caprylic acid (C8:0) would sup...
A novel lncRNA-miRNA-mRNA triple network identifies lncRNA TWF1 as an important regulator of miRNA and gene expression in coronary artery disease [0.03%]
一个新的lncRNA-miRNA-mRNA三重网络确定了lncRNA TWF1是冠状动脉疾病中miRNA和基因表达的重要调节因子
Liu Miao,Rui-Xing Yin,Qing-Hui Zhang et al.
Liu Miao et al.
Background: Long non-coding RNAs (lncRNAs) are involved in numerous physiological functions. Yet, their mechanisms in coronary artery disease (CAD) are not well understood. ...