Metabolomic signatures for liver tissue and cecum contents in high-fat diet-induced obese mice based on UHPLC-Q-TOF/MS [0.03%]
基于UHPLC-Q-TOF/MS的高脂饮食诱导型肥胖小鼠肝组织及盲肠内容物代谢标志物的研究
Hongying Cai,Zhiguo Wen,Kun Meng et al.
Hongying Cai et al.
Background: The incidence of obesity is increasing worldwide, and it is a risk factor for diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Our previous study had demonstrated that high-fat diet induced increa...
Ability of dietary factors to affect homocysteine levels in mice: a review [0.03%]
膳食因素影响同型半胱氨酸水平的研究进展及小鼠模型构建综述
Christine Brütting,Pia Hildebrand,Corinna Brandsch et al.
Christine Brütting et al.
Homocysteine is associated with several diseases, and a series of dietary factors are known to modulate homocysteine levels. As mice are often used as model organisms to study the effects of dietary hyperhomocysteinemia, we collected data a...
Serum metabolomics study of the association between dairy intake and the anti-müllerian hormone annual decline rate [0.03%]
血清代谢组学研究乳制品摄入与抗穆勒氏管激素年下降率关联性研究报告
Nazanin Moslehi,Rezvan Marzbani,Hassan Rezadoost et al.
Nazanin Moslehi et al.
Background: Dairy intake has been implicated in later ovarian aging but mechanism underlying the association is unknown. This study aimed to investigate (1) associations between dairy intake and metabolites previously sho...
Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6-12-year-old rural Chinese children: 2010-2012 China National Nutrition and Health Survey [0.03%]
中国农村6-12岁儿童全血铜、镁、锌水平与代谢综合征的横断面研究：基于2010-2012年中国居民营养与健康调查数据
Huidi Zhang,Qingqing Man,Pengkun Song et al.
Huidi Zhang et al.
Background: Metabolic syndrome (MetS) is significantly associated with the risk of cardiovascular disease and its prevalence is showing a trend of getting younger. Previous studies on the relationship between elements and...
Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity [0.03%]
左旋肉碱改善肝细胞烧伤引起的细胞和线粒体损伤的机制研究
Pengtao Li,Zhengguo Xia,Weichang Kong et al.
Pengtao Li et al.
Background: Impaired hepatic fatty acid metabolism and persistent mitochondrial dysfunction are phenomena commonly associated with liver failure. Decreased serum levels of L-carnitine, a amino acid derivative involved in ...
Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect [0.03%]
二氫杨梅素通过诱导自噬和NK细胞介导的杀伤效应抑制肝星状细胞从而改善肝纤维化
Xi Zhou,Li Yu,Min Zhou et al.
Xi Zhou et al.
Background: This study investigated the mechanisms underlying the preventive effect of dihydromyricetin (DHM) against liver fibrosis involving hepatic stellate cells (HSCs) and hepatic natural killer (NK) cells. ...
Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway [0.03%]
雌二醇通过PI3K/Akt途径调节肠道ABCG2促进尿酸排泄
Lei Liu,Tianyi Zhao,Lizhen Shan et al.
Lei Liu et al.
Objectives: The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy. In the current study, we aimed t...
Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study [0.03%]
中国中老年人群BMI、腰围、腰高比及其变化与血尿酸风险的独立和联合作用：基于全国性队列研究的结果
Zonglei Zhou,Kunpeng Li,Xianzhi Li et al.
Zonglei Zhou et al.
Background: Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. The associations of hyperuricemia risk with changes in obesity status...
Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle [0.03%]
氯喹对人类骨骼肌中mTORC1活化和蛋白质合成的影响
Michael S Borack,Jared M Dickinson,Christopher S Fry et al.
Michael S Borack et al.
Background: Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested th...
Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets [0.03%]
代谢适应与低能量饮食的体重和脂肪量减轻幅度较小有关
Catia Martins,Jessica Roekenes,Barbara A Gower et al.
Catia Martins et al.
Background: The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes....