A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD [0.03%]
新型小分子化合物TOIDC通过SREBP1依赖性信号抑制脂质生成以遏制MAFLD的发展
Yaodi Shao,Zhi Yao,Junyi Zhou et al.
Yaodi Shao et al.
Background: Inhibition of hepatic lipogenesis is widely regarded as an effective treatment for metabolic-associated fatty liver disease (MAFLD), although numerous related drugs have failed to reach clinical application. T...
Abdominal obesity in COPD is associated with specific metabolic and functional phenotypes [0.03%]
COPD中的腹部肥胖与特定的代谢和功能表型有关
Clayton L Cruthirds,Nicolaas E P Deutz,Yani G G Mizubuti et al.
Clayton L Cruthirds et al.
Background: Abdominal obesity (AO) is linked to reduced health status and mortality. While it is known that AO is prevalent in chronic obstructive pulmonary disease (AO-COPD), the specific metabolic and functional consequ...
Preoperative administration of branched-chain amino acids reduces postoperative insulin resistance in rats by reducing liver gluconeogenesis [0.03%]
术前应用支链氨基酸能通过降低肝脏糖异生来降低大鼠的术后胰岛素抵抗
Jin Zhang,Rui Chi,Yunpeng Zhang et al.
Jin Zhang et al.
Background: Postoperative insulin resistance (PIR) represents an important characteristic of metabolic response following surgical injury. Clinical outcomes are negatively correlated to postoperative insulin resistance an...
Beneficial effect of time-restricted eating on blood pressure: a systematic meta-analysis and meta-regression analysis [0.03%]
限时饮食对血压有益影响的系统荟萃分析和荟萃回归分析
Weihao Wang,Ran Wei,Qi Pan et al.
Weihao Wang et al.
Background: As a cardiometabolic disease, hypertension has shown an obvious upward trend, becoming a global epidemic chronic disease. Lifestyle intervention is a fundamental method for lowering blood pressure. This system...
Glucosamine delays the progression of osteoporosis in senile mice by promoting osteoblast autophagy [0.03%]
葡萄糖胺通过促进成骨细胞自噬延缓老年小鼠骨质疏松的进展
Wei Su,Chen Lv,Lingtuo Huang et al.
Wei Su et al.
Background: Senile osteoporosis (SOP) is one of the most prevalent diseases that afflict the elderly population, which characterized by decreased osteogenic ability. Glucosamine (GlcN) is an over-the-counter dietary suppl...
Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota [0.03%]
姜黄素通过肠道微生物群改善高脂饮食喂养的小鼠的胰岛素敏感性
Yue Zhong,Yang Xiao,Jing Gao et al.
Yue Zhong et al.
Background: Insulin resistance precedes metabolic syndrome which increases the risk of type 2 diabetes and cardiovascular disease. However, there is a lack of safe and long-lasting methods for the prevention and treatment...
Dietary oxalate-calcium balance and the incidence of hypertension and chronic kidney disease: a prospective study among an Asian population [0.03%]
膳食草酸钙平衡与高血压和慢性肾脏病发生率的关系：在亚洲人群中的一项前瞻性研究
Parvin Mirmiran,Zahra Bahadoran,Fereidoun Azizi
Parvin Mirmiran
Background: The potential effects of dietary oxalate (Ox) intake on cardio-renal function have remained unestablished. We evaluated the effect of usual Ox intake and its interaction with dietary calcium (Ca) on incident h...
The association between parenteral nutrition and pancreatic injury in adult patients: a retrospective observational study [0.03%]
成人患者肠外营养与胰腺损伤关联的回顾性观察研究
Xiao-Min Zhang,Yi-Quan Zhou,Yan-Ping Wan et al.
Xiao-Min Zhang et al.
Background and objective: Patients on parenteral nutrition (PN) are at high risk of both liver and pancreatic injury. More efforts were focused on liver, however, limited data is available to evaluate the effects of PN on...
Analysis of different adipose depot gene expression in cachectic patients with gastric cancer [0.03%]
胃癌恶病质患者不同脂肪室基因表达的分析研究
Jun Han,Zuoyou Ding,Qiulin Zhuang et al.
Jun Han et al.
Purpose: This study aimed to identify the differentially expressed genes (DEGs) that contributed to the different amount of fat loss between subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) among cachec...
Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss [0.03%]
膳食蛋白质和血糖指数在一个营养计划中处理能量限制的减肥后的体重反弹导致的胰岛素抵抗问题
Fernando Vidal-Ostos,Omar Ramos-Lopez,Susan A Jebb et al.
Fernando Vidal-Ostos et al.
Background and aim: The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined. ...