High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats [0.03%]
富含洋葱的高胆固醇饮食可影响wistar大鼠肠系膜微血管内皮依赖性舒张及nadph氧化酶活性
Diana González-Peña,Javier Angulo,Susana Vallejo et al.
Diana González-Peña et al.
Background: The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular ...
Inflammation rapidly modulates the expression of ALDH1A1 (RALDH1) and vimentin in the liver and hepatic macrophages of rats in vivo [0.03%]
炎症快速调节大鼠肝脏和肝巨噬细胞中ALDH1A1(RALDH1)及波形蛋白的表达
Kyoko Ito,Reza Zolfaghari,Lei Hao et al.
Kyoko Ito et al.
Background: Members of the ALDH1 protein family, known as retinal dehydrogenases (RALDH), produce retinoic acid (RA), a metabolite of vitamin A, and may also oxidize other lipid aldehydes. Of three related ALDH1 genes, AL...
Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study [0.03%]
种族、性别、FADS基因多态性以及口服避孕药使用影响加拿大青年人的Δ5-和Δ6-脱饱和酶指数及血浆二十二碳六烯酸水平：横断面研究
Salma A Abdelmagid,Shannon E Clarke,Kaitlin Roke et al.
Salma A Abdelmagid et al.
Background: There is great interest in the relationship between polyunsaturated fatty acids and health. Yet, the combinatory effect of factors such as sex, ethnicity, genetic polymorphisms and hormonal contraceptives (HC)...
Identification of residues/sequences in the human riboflavin transporter-2 that is important for function and cell biology [0.03%]
鉴定参与人核黄素转运蛋白-2功能及细胞生物学的重要残基/序列
Veedamali S Subramanian,Rubina Kapadia,Abhisek Ghosal et al.
Veedamali S Subramanian et al.
Background: Riboflavin (RF) is essential for normal cellular metabolic activities. Human cells obtain RF from their surroundings via a carrier-mediated process that involves RF transporters -1, -2 & -3 (hRFVT -1, -2 & -3;...
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer [0.03%]
简易代谢管理脑癌疗效监测工具：葡萄糖-酮体比率计算仪
Joshua J Meidenbauer,Purna Mukherjee,Thomas N Seyfried
Joshua J Meidenbauer
Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic f...
The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults [0.03%]
APOB插入/删除多态性（rs17240441）影响健康成年人的餐后脂血症
Karani Santhanakrishnan Vimaleswaran,Anne M Minihane,Yue Li et al.
Karani Santhanakrishnan Vimaleswaran et al.
Background: Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have ...
The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice [0.03%]
β3肾上腺素受体激动剂（CL-316,243）恢复2型糖尿病小鼠下调的脂肪酸氧化基因的表达
Amit Kumar,Joseph Shiloach,Michael J Betenbaugh et al.
Amit Kumar et al.
Background: The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple other metabolic abnormalities that occur with T2D, including insulin resistance and dyslipidemia. To advance T2D prevention a...
Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism [0.03%]
通过MAPKs依赖机制，新型PPAR-γ激动剂芦丁抑制TGF-β挽救β受体刺激的实验大鼠心肌损伤
Neha Rani,Saurabh Bharti,Jagriti Bhatia et al.
Neha Rani et al.
Background: Pharmacological stimulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) has been recognized as a molecular switch in alleviating myocardial injury through modulating oxidative, inflammatory a...
AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid [0.03%]
α亚麻酸的抗肥胖作用需要AMP活化蛋白激酶
Xihong Zhou,Weiche Wu,Jingqing Chen et al.
Xihong Zhou et al.
Background: n-3 long chain polyunsaturated fatty acid (n-3 LC PUFA) increases β-oxidation and limits lipid accumulation in adipocytes. The current study was conducted to determine whether their precursor alpha-linolenic ...
Marc J Mathews,Leon Liebenberg,Edward H Mathews
Marc J Mathews
Background: Diet has a significant relationship with the risk of coronary heart disease (CHD). Traditionally the effect of diet on CHD was measured with the biomarker for low-density lipoprotein (LDL) cholesterol. However...