The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases [0.03%]
肌浆网钙依赖的触发机制及其在心血管疾病中的潜在作用
Yoshiaki Kawase,Roger J Hajjar
Yoshiaki Kawase
The cardiac isoform of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA2a) is a calcium ion (Ca(2+)) pump powered by ATP hydrolysis. SERCA2a transfers Ca(2+) from the cytosol of the cardiomyocyte to the lumen of the sarcoplasmic...
Time course of events in acute coronary syndromes: implications for clinical practice from the GRACE registry [0.03%]
急性冠脉综合征事件发生的时间进程：来自GRACE注册研究对临床实践的意义
Keith A A Fox,Frederick A Anderson Jr,Shaun G Goodman et al.
Keith A A Fox et al.
Background: The time course of events after acute coronary syndromes might influence the timing and duration of therapeutic interventions. We investigated the impact of risk status and ST-segment category at presentation....
Does the angiotensin receptor blocker telmisartan prevent morbid atherosclerotic events? [0.03%]
_telmisartan能否预防动脉粥样硬化事件？
Jay N Cohn
Jay N Cohn
ONTARGET has established the efficacy of the angiotensin receptor blocker (ARB) telmisartan to slow disease progression and delay or prevent morbid events in patients with atherosclerosis. Although the study failed to confirm additive effic...
Do patients with long QT syndrome remain at risk for sudden cardiac death after 40 years of age? [0.03%]
长QT间期综合征患者在40岁以后是否仍有猝死风险？
Pieter G Postema,Arthur A M Wilde
Pieter G Postema
Long QT syndrome (LQTS) is an inherited arrhythmic disorder in which patients display a propensity for prolongation of the heart rate-corrected QT interval (QTc) and for sudden cardiac death. To obtain a better understanding of this disease...
Douglas S Moodie
Douglas S Moodie
Diagnosis of cardiac anomalies in offspring of women with congenital heart disease: is fetal echocardiography enough? [0.03%]
母亲患有先天性心脏病的后代心脏异常诊断：胎儿超声心动图足够吗？
Lindsey D Allan
Lindsey D Allan
Detailed follow-up in a series of 276 mothers with congenital heart disease--whose children are at increased risk of heart disease--demonstrated that, although a fetal echocardiography is reliable in detecting major disease, some minor lesi...
Balloon valvuloplasty of the aortic valve in children: a surgical view [0.03%]
儿童主动脉瓣 balloon 成形术的外科观点
James L Monro
James L Monro
The paper by Fratz et al. describes the follow-up of 188 children who had balloon aortic valvuloplasty (AoVP) between 1986 and 2004. Moderate or severe aortic regurgitation occurred more often in the 68 neonates--in whom there was significa...
Skeletal myoblast transplantation: no MAGIC bullet for ischemic cardiomyopathy [0.03%]
骨骼肌前体细胞移植不能成为缺血性心肌病的“特效药”
Howard J Eisen
Howard J Eisen
Therapies for end-stage heart failure are limited by the donor shortage for heart transplantation and the shortcomings of left ventricular assist devices for destination therapy. Treatments that use stem cells to 'rebuild' the myocardium ar...
Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells [0.03%]
心脏细胞治疗的影像学评估——治疗性干细胞移植后的体内示踪及生物学特性分析
Hung Q Ly,John V Frangioni,Roger J Hajjar
Hung Q Ly
Clinical trials in cardiac cell-based therapy (CBT) have demonstrated the immense potential of stem progenitor cells (SPCs) to repair the injured myocardium. The bulk of evidence so far has shown that CBT can lead to structural and function...
Noninvasive radionuclide imaging of cardiac gene therapy: progress and potential [0.03%]
非侵入性放射核素心脏基因治疗成像：进展与前景
Asimina Hiona,Joseph C Wu
Asimina Hiona
Over the past decade, several clinical trials have evaluated the efficacy of cardiac-specific gene therapy. Despite encouraging results in basic research and preclinical studies, most of the recent large, randomized, placebo-controlled card...