The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2 [0.03%]
激素受体阳性且HER2共表达的乳腺癌治疗中激素治疗的作用
Aleix Prat,José Baselga
Aleix Prat
Approximately half of breast cancers that overexpress human epidermal growth factor receptor 2 (HER2) also express hormone receptors (HRs). Although HR positivity predicts efficacy of endocrine agents, preclinical and clinical data suggest ...
Drug Insight: intracellular inhibitors of HER2--clinical development of lapatinib in breast cancer [0.03%]
药物再评价新策略：乳腺癌治疗中lapatinib的临床应用与发展
David A Cameron,Steven Stein
David A Cameron
Targeting the human epidermal growth factor receptor type 2 (HER2) in breast cancer patients whose tumors overexpress HER2 has been clearly demonstrated to be effective in clinical trials with the monoclonal antibody trastuzumab. Not all pa...
Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications [0.03%]
表皮生长因子受体依赖途径和血管内皮生长因子依赖途径的联合靶向：理论依据、前期研究及临床应用
Giampaolo Tortora,Fortunato Ciardiello,Giampietro Gasparini
Giampaolo Tortora
Cellular heterogeneity, redundancy of molecular pathways and effects of the microenvironment contribute to the survival, motility and metastasis of cells in solid tumors. It is unlikely that tumors are entirely dependent on only one abnorma...
Radiation therapy improves survival in patients with pancreatic adenocarcinoma [0.03%]
放疗可改善胰腺癌患者生存率
Felix Y Feng,Edgar Ben-Josef
Felix Y Feng
Lajos Pusztai
Lajos Pusztai
Chemotherapy for muscle-invasive bladder cancer treated with definitive radiotherapy: persisting uncertainties [0.03%]
肌层浸润性膀胱癌根治性放疗后辅助化疗的不确定性仍然存在
Toni K Choueiri,Derek Raghavan
Toni K Choueiri
Radical cystectomy for invasive bladder cancer remains the standard of care in many parts of the world, including North America and many parts of Europe; however, a large body of international experience from single institutions and coopera...
Adjuvant EBRT improves survival in patients with lymph-node-negative pancreatic cancer [0.03%]
辅助放疗可改善淋巴结阴性的胰腺癌患者的预后生存率
Lisa J Hazard,Jonathan D Tward,Dennis C Shrieve
Lisa J Hazard
The CCR9-CCL25 axis mediates melanoma metastasis to the small intestine [0.03%]
CCR9-CCL25轴介导黑色素瘤向小肠转移
Joost van den Oord
Joost van den Oord
Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? [0.03%]
肿瘤血管生成疗法开发的血管生成生物标志物：工具或装饰？
Cristiana Sessa,Aymeric Guibal,Gianluca Del Conte et al.
Cristiana Sessa et al.
Since 2004, four antiangiogenic drugs have been approved for clinical use in patients with advanced solid cancers, on the basis of their capacity to improve survival in phase III clinical studies. These achievements validated the concept in...
Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy [0.03%]
伊罗替尼治疗NF2相关前庭神经鞘瘤的听觉和影像学反应分析
Scott R Plotkin,Marybeth A Singh,Caroline C O&#x;Donnell et al.
Scott R Plotkin et al.
Background: A 48-year-old man presented to a neurologist with complaints of bilateral hearing loss and tinnitus. The patient was a member of a large family affected by neurofibromatosis type 2 and first noted hearing loss...