The impact of histopathologic diagnosis on the proper management of testis neoplasms [0.03%]
病理诊断对睾丸肿瘤合理治疗的影响
Giovanni Ponti,Maurilio Ponzoni,Andrés Jm Ferreri et al.
Giovanni Ponti et al.
Background: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months...
Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance [0.03%]
鸟氨酸脱羧酶抑制剂DFMO与抗炎药磺溴派特联合预防结肠腺瘤的临床研究重大进展
Michael B Sporn,Waun Ki Hong
Michael B Sporn
In a randomized, placebo-controlled, double-blind clinical trial by Meyskens et al. the combination of difluoromethylornithine and sulindac has been shown to be strikingly effective for prevention of sporadic colorectal adenomas. This conco...
A Gregory Sorensen,Tracy T Batchelor,Patrick Y Wen et al.
A Gregory Sorensen et al.
The current method for assessing the response to therapy of glial tumors was described by Macdonald et al. in 1990. Under this paradigm, response categorization is determined on the basis of changes in the cross-sectional area of a tumor on...
Combined transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma [0.03%]
肝癌的联合动脉化疗栓塞与射频消融治疗
Myron Schwartz,Joshua Weintraub
Myron Schwartz
Transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are both efficacious in treating well-selected patients who have hepatocellular carcinoma (HCC). The sequential combination of these two modalities has a sound theoret...
Strategies for discovering novel cancer biomarkers through utilization of emerging technologies [0.03%]
利用新兴技术发现新型癌症生物标志物的战略
Vathany Kulasingam,Eleftherios P Diamandis
Vathany Kulasingam
The introduction of technologies such as mass spectrometry and protein and DNA arrays, combined with our understanding of the human genome, has enabled simultaneous examination of thousands of proteins and genes in single experiments, which...
The ROC 'n' role of the multiplex assay for early detection of ovarian cancer [0.03%]
多参数检测在卵巢癌早期诊断中的作用
Alpa M Nick,Anil K Sood
Alpa M Nick
In order to overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA125 is used to assess response to chemotherapy, detect recurrence, and distinguish malignant...
Should surgery followed by whole-brain radiation therapy be the standard treatment for single brain metastasis? [0.03%]
单独脑转移瘤患者应接受手术加全脑放疗吗？
David W Andrews
David W Andrews
This Practice Point commentary discusses the results of a retrospective analysis conducted by Rades et al. that examined surgical intervention followed by whole-brain radiation therapy (WBRT) and WBRT alone in patients with a single brain m...
Andrew M Evens,Martin Hutchings,Volker Diehl
Andrew M Evens
Significant advances in the biology and treatment of Hodgkin lymphoma (HL) have been accomplished over the past decades. In a landmark study, DeVita and colleagues showed that half of patients with advanced-stage HL experienced long-term di...
Donald L Morton,Alistair J Cochran,John F Thompson
Donald L Morton
Clinical evidence does not support the use of adjuvant radiotherapy in pancreatic cancer [0.03%]
临床证据不支持胰腺癌辅助放疗
John P Neoptolemos
John P Neoptolemos