Does pegylated interferon alpha-2b confer additional benefit in the adjuvant treatment of high-risk melanoma? [0.03%]
聚乙二醇干扰素α-2b能否提高高危黑色素瘤辅助治疗的疗效？
John M Kirkwood,Hussein A Tawbi,Ahmad A Tarhini et al.
John M Kirkwood et al.
High-dose interferon (IFN)alpha-2b has shown benefits in the adjuvant treatment of melanoma, but relapse-free and overall survival remain poor, despite the use of chemotherapy, vaccines, and combinations of these modalities. Questions remai...
Which questions remain unanswered following the successful development of sorafenib in hepatocellular carcinoma? [0.03%]
索拉非尼成功应用于肝细胞癌之后仍有哪些问题亟待回答？
Keith T Flaherty,Weijing Sun
Keith T Flaherty
Investigation of the effects of various antiangiogenic agents in the therapy of solid tumors has been a dominant theme in oncology for the past decade. Hepatocellular carcinoma has joined the short list of tumor types for which single-agent...
How does extended lymphadenectomy influence practical care for patients with gastric cancer? [0.03%]
扩大淋巴结切除对胃癌患者的治疗有何影响？
Ilfet Songun,Cornelis J H van de Velde
Ilfet Songun
The recurrence and survival rates in patients with curable gastric cancer remain suboptimal. Debate on the optimal extent of lymphadenectomy for the surgical treatment of these patients is, therefore, still ongoing. A randomized, controlled...
A case of prolonged disease-free survival in a patient with choroidal metastasis from breast cancer [0.03%]
一例乳腺癌脉络膜转移长期无病生存患者的病例报告
Raymond W Jang,Mary Doherty,J Jill Hopkins et al.
Raymond W Jang et al.
Background: A 57-year-old woman presented with distorted vision and decreased visual acuity (finger count only) in her left eye, 6 years after she had undergone a lumpectomy, lymph-node dissection, and radiation therapy f...
Monica Morrow
Monica Morrow
Epothilones: tubulin polymerization as a novel target for prostate cancer therapy [0.03%]
埃坡托比林：作为一种治疗前列腺癌的新型药物作用于聚合β微管蛋白
James J Lee,W Kevin Kelly
James J Lee
Microtubules are vital and dynamic cellular organelles and many agents have been developed that target them. The cytotoxic effects of taxanes and epothilones are mediated by stabilization of microtubule dynamics. Taxanes are one of the most...
Mammography in developing countries: the risks associated with globalizing the experiences of the Western world [0.03%]
发展中国家的乳腺摄影：全球推广西方世界经验的风险
Alan A Arslan,Silvia C Formenti
Alan A Arslan
Vincent T DeVita Jr
Vincent T DeVita Jr
Should screening MRI be included in surveillance for patients treated with breast-conserving therapy? [0.03%]
乳腺保守治疗患者随访中是否需要加入筛查MRI？
Murray Rebner,Inga Grills,Frank Vicini
Murray Rebner
Breast MRI has been shown to provide diagnostic benefit in multiple situations. It has proved useful in the evaluation of ruptured silicone implants and in the evaluation of patients with cancerous axillary lymph nodes, a negative mammogram...
Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma [0.03%]
一名胶质瘤患者的18F-FHBG正电子发射断层扫描非侵入性检测治疗性细胞毒性T细胞
Shahriar S Yaghoubi,Michael C Jensen,Nagichettiar Satyamurthy et al.
Shahriar S Yaghoubi et al.
Background: A 57-year-old man had been diagnosed with grade IV glioblastoma multiforme and was enrolled in a trial of adoptive cellular immunotherapy. The trial involved infusion of ex vivo expanded autologous cytolytic C...