TPEN attenuates neuronal ferroptosis in ischemic brain injury via GPR39-mediated PI3K/AKT signaling activation [0.03%]
TPEN通过GPR39介导的PI3K/AKT信号激活缓解缺血性脑损伤中的神经元铁死亡
Fei Li,Zhenhong Li
Fei Li
Objectives: Brain injury involves neuronal ferroptosis, and the zinc chelator TPEN exhibits neuroprotective potential. However, its mechanisms remain unclear. GPR39, a G protein-coupled receptor, participates in cell surv...
Predictive value of neutrophil-to-lymphocyte ratio for mortality in surgically treated patients with acute subdural hematoma [0.03%]
中性粒细胞与淋巴细胞比值对急性硬膜下血肿手术患者预后的预测价值分析
Shilong Fu,Zongping Wu,Guofeng Wang
Shilong Fu
Objectives: Despite prompt surgical intervention, acute subdural hematoma (ASDH) following traumatic brain injury has a high mortality rate. This study aimed to evaluate the predictive value of neutrophil-to-lymphocyte ra...
The potential role of miR-4706 during the development of the carotid artery stenosis through BMPR2 [0.03%]
miR-4706通过BMPR2在颈动脉狭窄发病过程中发挥的作用研究
Xuehui Zhang,Qian Zhang,Jie Shu et al.
Xuehui Zhang et al.
Objectives: Carotid artery stenosis (CAS) is a common atherosclerotic disease among the elderly. The expression and mechanism of action of miR-4706 in CAS are still unclear. This study aims to elucidate the functional rol...
Functional and mechanistic study of miR-148a-3p as a novel biomarker for type 2 diabetic peripheral neuropathy [0.03%]
miR-148a-3p作为2型糖尿病外周神经病变新型生物标志物的功能及机制研究
Chaoqiang Liu,Jinsu Chen,Guangfei Xu et al.
Chaoqiang Liu et al.
Background: Type 2 diabetic peripheral neuropathy (T2DM-DPN) not only raises amputation risk but also strains healthcare resources, making the identification of diagnostic biomarkers crucial for early intervention and tar...
Risk factors for fluid retention associated with clazosentan after subarachnoid hemorrhage: a retrospective study [0.03%]
一项关于蛛网膜下腔出血后与clazosentan相关的液体潴留风险因素的回顾性研究
Masao Sekimoto,Toru Imai,Yuto Suzuki et al.
Masao Sekimoto et al.
Objectives: Clazosentan, a drug used to prevent delayed cerebral vasospasm, is frequently associated with fluid retention-related adverse events (AEs), such as pulmonary edema. This study aimed to identify risk factors fo...
Endovascular treatment beyond 24 hours for large vessel occlusion strokes selected by CT perfusion [0.03%]
采用CTP选择的大血管闭塞型卒中患者超过24小时的时间窗内接受血管内治疗的效果
Changzhu Wu,Xianwei Wang,Lingling Zhang et al.
Changzhu Wu et al.
Background: The role that endovascular treatment (EVT) may play in stroke patients with large vessel occlusion (LVO) who are treated beyond 24 h after onset is unclear. In this study, we aimed to examine the efficacy and ...
Identification of taurine metabolism related subtypes in gliomas and construction of risk models to predict prognosis and immune microenvironment [0.03%]
胶质瘤中牛磺酸代谢相关亚型的识别及预后和免疫微环境预测模型的构建
Guodong He,Jingnan Huang,Zhaodi Zeng et al.
Guodong He et al.
Background: Glioma is a prevalent and aggressive brain tumor, and taurine metabolism may play a crucial role in suppressing tumor progression. This research seeks to identify taurine metabolism-related glioma subtypes and...
Simultaneous inhibition of pannexin-1 by probenecid and caspases by Z-VAD-fmk attenuates apoptosis and necroptosis in a rat model of cerebral ischemia-reperfusion [0.03%]
石蜡兔耳模型中施加EGF对几种损伤的保护作用
Emine Colak,Semih Oz,Emre Ozkara et al.
Emine Colak et al.
Objectives: Ischemia-reperfusion injury activates both apoptotic and necroptotic pathways, contributing to neuronal damage. This study aimed to investigate the effects of pannexin-1 inhibition by probenecid on these pathw...
Yuting Zhao,Ning Xu,Lily Liang et al.
Yuting Zhao et al.
Objective: To investigate the ameliorative effect of total ginseng protein (GP) on Parkinson's disease (PD) in vivo and in vitro and its effect on the intestinal flora. ...
Effectiveness of sesame oil and melatonin on P53 level in spinal cord injury of rat menopausal model [0.03%]
芝麻油和褪黑素对绝经后脊髓损伤大鼠P53蛋白水平的影响研究
Maryam Soleimani,Mohammad Mashhadi Ebrahim Tehrani,Seyed Behnamedin Jameie et al.
Maryam Soleimani et al.
Objective: Identifying mechanisms that prevent neuronal inflammation and apoptosis can offer promising approaches to prevent and treat neuronal degeneration in spinal cord injury (SCI). The latest research confirms the an...