Predictors of futile recanalization following mechanical thrombectomy in acute ischemic stroke: a single-center retrospective cohort study [0.03%]
急性缺血性卒中机械取栓术后无复流的预测因素：单中心回顾性队列研究
Wu Yuexin,Xinhui Li,Wenjian Su et al.
Wu Yuexin et al.
Background: Despite successful recanalization rates exceeding 85% with mechanical thrombectomy, approximately half of acute ischemic stroke patients with large vessel occlusion experience futile recanalization-vessel reop...
METTL3 improves spinal cord injury-associated locomotor function via SIRT1 m6A modification and regulation of neuronal ferroptosis [0.03%]
METTL3通过SIRT1的m6A修饰和对神经元铁死亡的调节改善脊髓损伤相关的运动功能
Ying Chen,Kaibin Zeng,Gongzhou Chen et al.
Ying Chen et al.
Objective: Inhibition of neuronal ferroptosis is considered crucial for the recovery of locomotor function following spinal cord injury (SCI). We explored the mechanism of methyltransferase-like 3 (METTL3) mediating sirtu...
HSP47 inhibitor Col003 may attenuates neurological impairment in chronic ischemic stroke rats by inhibiting LCN2 [0.03%]
热休克蛋白47抑制剂Col003可通过抑制LCN2缓解慢性卒中大鼠神经功能缺损
Kejian Zhou,Yuliang Xie,Xiaoyun Xie et al.
Kejian Zhou et al.
Objectives: Ischemic stroke often causes severe neurological impairments. Our previous studies showed that Col003, a heat shock protein (HSP47) inhibitor, has neuroprotective effects in acute ischemic stroke, but its role...
Elevated auditory radiation integrity in migraine: evidence from diffusion tensor imaging [0.03%]
偏头痛患者的听觉放射纤维结构完整性升高——弥散张量成像证据
Eva Kiparizoska,Toshikazu Ikuta
Eva Kiparizoska
Background: Auditory symptoms are a common feature in migraines, yet the underlying neural basis is poorly understood. Prior studies have identified thalamic alterations in patients with migraines, particularly in the med...
Causal relationships between micronutrients and intracerebral hemorrhage: univariable and multivariable Mendelian randomization [0.03%]
微量营养素与脑内出血之间的因果关系：单变量和多变量孟德尔随机化
Xiang Niu,Ziyu Zhao,Xiaoxi Wang et al.
Xiang Niu et al.
Background: Intracranial hemorrhage (ICH) prevalence is increasing, yet its genetic risk factors and micronutrient associations remain unclear. Methods: ...
The protective role of miR-672-3p inhibition against ketamine-induced neurological impairment [0.03%]
miR-672-3p抑制对氯胺酮所致神经功能损伤的保护作用
Jianghong Liu,Ruina Guo,Xizhong Ma et al.
Jianghong Liu et al.
Objective: Anesthetic drugs have toxic effects on the central nervous system, leading to cognitive dysfunction. This study aimed to explore the potential protective effect of miR-672-3p against ketamine-induced neurologic...
An explainable modified convolutional mixer neural network-based deep learning framework for accurate brain tumor detection and classification [0.03%]
一种改进的卷积混合器神经网络可解释性深度学习框架用于准确的大脑肿瘤检测和分类
S Selva Birunda,M Kaliappan,R Ramana
S Selva Birunda
Objectives: Brain tumors (BTs) pose a severe health risk due to their heterogeneous nature and low survival rates. Traditional models often struggle with computationally expensive and require extensive training time. To a...
Silencing IncRNA BACE1-AS alleviates neuronal injury and neurological deficits after ischemic stroke via targeting miR-103a-3p [0.03%]
沉默IncRNA BACE1-AS通过靶向miR-103a-3p缓解缺血性脑卒中后的神经元损伤和神经功能缺损
Kaijie Yu,Fang Liu,Tianrui Yu et al.
Kaijie Yu et al.
Objective: To investigate the role of lncRNA BACE1-AS in neuronal injury and neurological deficits after ischemic stroke and explore its underlying molecular mechanism. ...
Preclinical safety and performance evaluation of a novel, open-cell intracranial vascular stent [0.03%]
一种新型颅内血管支架的药理学安全性和性能评估
Peifeng Guan,Yilin Liu,Xiangdong Liu et al.
Peifeng Guan et al.
Objective: We report a preclinical study of a novel intracranial vascular stent for aneurysm occlusion to test the hypothesis that the open-cell intracranial vascular stent developed in China have similar performance to t...
SIRT1 activates autophagy through Smad3 deacetylation and inhibits microglia activation to relieve SCI [0.03%]
SIRT1通过去乙酰化Smad3激活自噬并抑制微胶质细胞活化以缓解脊髓损伤
Hongbo Chen,Rongmei Li,Ya Li et al.
Hongbo Chen et al.
Background: In the state of spinal cord injury (SCI), microglia over-activate and release inflammatory factors, which aggravate SCI. The neuroprotective factor known as sirtuin 1 (SIRT1) is intricately linked to the activ...