Dexmedetomidine protects against cerebral ischemia-reperfusion injury in mice by interfering with the crosstalk between autophagy and ferroptosis [0.03%]
舒芬太尼通过干扰自噬与铁死亡串话保护小鼠免受脑缺血再灌注损伤
Cong Luo,Yi Ou,Yujie Xu et al.
Cong Luo et al.
Objective: Previous studies show DEX protects against focal cerebral ischemia by hindering autophagy. However, the exact mechanisms are unclear. This study hypothesizes DEX may protect neurons by regulating the crosstalk ...
Kenpaullone attenuates amyloid-beta deposition and neuroinflammation, improving memory in a 5XFAD mouse model of Alzheimer's disease [0.03%]
Kenpaullone减轻阿尔茨海默病5XFAD小鼠模型中的淀粉样蛋白-β沉积和神经炎症，改善记忆功能
Shukur Wasman Smail,Azad Hasan Kheder,Hero Khalid Mustafa et al.
Shukur Wasman Smail et al.
Kenpaullone is known for its neuroprotective and anti-inflammatory properties. We explored the potential of a specific intervention to influence cognitive abilities and disease-related brain changes in a mice model replicating key aspects o...
Electroacupuncture improved depressive behaviors and synaptic plasticity of post-stroke depressed mice via inhibiting the JNK signaling pathway [0.03%]
电针通过抑制JNK信号通路改善抑郁行为和卒中后抑郁症小鼠的突触可塑性
Chunhua Lai,Weimin He,Hua Yang et al.
Chunhua Lai et al.
Objectives: The safety and effectiveness of electroacupuncture (EA) in treating depression have been scientifically validated. Recent evidence indicates that the c-Jun N-terminal kinase (JNK) pathway is a therapeutic targ...
Efficacy and safety of hematopoietic and mesenchymal stem cells in multiple sclerosis: a meta-analysis [0.03%]
造血干细胞和间充质干细胞治疗多发性硬化有效性和安全性的系统评价和 meta 分析
Shampa Maji,Archana Mishra,Anand Srinivasan et al.
Shampa Maji et al.
Objective: Currently available treatment options for multiple sclerosis (MS) have limited efficacy and/or safety concerns. Various mesenchymal stem cells and hematopoietic stem cells have been evaluated in recent clinical...
Cognitive impairment and quality of life in patients with carotid artery stenosis pre-revascularization: a scoping review [0.03%]
血管重建前颈动脉狭窄患者的认知障碍和生活质量：一项概要性综述
Mohammad Minwer Alnaeem
Mohammad Minwer Alnaeem
Background: Carotid artery stenosis (CAS) reduces cerebral blood flow and is frequently associated with cognitive impairment and reduced quality of life (QoL), particularly in severe CAS. Although carotid revascularizatio...
Differential neuroprotective mechanisms of rosemary and carnosic acid in cerebral ischemia-reperfusion injury [0.03%]
迷迭香和鼠尾草酸在脑缺血再灌注损伤中不同的神经保护机制研究
Wanxian Li,Cuiying Liu,Can Xu et al.
Wanxian Li et al.
Objective: Rosemary is a traditional Chinese medicinal herb recognized for its therapeutic potential in cardiovascular and cerebrovascular diseases. Its primary active constituent, carnosic acid, has been shown to reduce ...
Multimerin-1 modulates macrophage M2 polarization and enhances tumor cell stemness in glioblastoma [0.03%]
多形性胶质母细胞瘤中多元蛋白-1通过调节M2巨噬细胞极化促进肿瘤干细胞样特性增强
Chao Huang,Xue-Bin Yu,Yong-Zhi Zhou et al.
Chao Huang et al.
Objectives: Glioblastoma (GBM) is one of the most aggressive brain tumors, with a poor prognosis. Brain tumor stem cells (BTSCs) play a central role in GBM progression and recurrence. This study aimed to identify key BTSC...
ITGA5 drives glioblastoma progression through SLK-mediated activation of the PI3K-Akt pathway [0.03%]
ITGA5通过SLK介导的PI3K-Akt途径激活促进胶质母细胞瘤进展
Hongkang Hu,Xingfei Fan,Jialiang Wei et al.
Hongkang Hu et al.
Glioblastoma (GBM) is the most common type of malignant primary brain tumor and exhibits a rising trend in both incidence and mortality rates. Several studies have shown Integrin Subunit Alpha 5 (ITGA5) has oncogene-promoting functions in G...
Evaluating the therapeutic efficacy of a Benzofuran-Enaminone derivative for the management of Alzheimer's disease (AD)-like pathology in rats through regulating the expression of apoptosis and AD-related genes [0.03%]
评估苯并呋喃-烯胺酮衍生物通过调节凋亡和与阿尔茨海默病相关基因的表达治疗阿尔茨海默病样病理损害的疗效
Hanan F Aly,Ghadha Ibrahim Fouad,Wagdy K B Khalil et al.
Hanan F Aly et al.
Background: Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder. There is currently no promising cure for AD; the available treatments can only alleviate the symptoms. ...
Differential expression of D2 receptor isoforms in the mesocorticolimbic system after treatment with modafinil and its rewarding combination with citalopram in rats [0.03%]
莫达菲尼及其与西酞普兰奖励性联合用药对中皮质边缘系统D2受体异构体的差异表达的影响
Luz M Molina-Martínez,Jesús E Yepez,Jorge Juárez
Luz M Molina-Martínez
Background: Psychostimulants induce neuroplastic changes in the mesocorticolimbic system associated with the expression of the D2 receptor, which has two isoforms: D2long (D2L) and D2short (D2S). These isoforms seem to pa...