Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway [0.03%]
Sophocarpine通过调节AMPK/NF-κB信号通路预防LPS和IFN-γ刺激的BV-2小胶质细胞氧化应激和神经炎症
Shupeng Guo,Ti Li,Lili Luan et al.
Shupeng Guo et al.
Background: Microglia can be continuously activated to produce proinflammatory cytokines and reactive oxygen species, leading to progressive neurodegeneration. Sophocarpine (ScP) has been reported to exhibit neuroprotecti...
Association of hemoglobin glycation index with poor prognosis in critically ill patients with ischemic stroke: a cohort study [0.03%]
糖化指数与缺血性卒中重症患者不良预后的关系：群组研究
Kaiwu Meng,Sushuang Yang,Yiran Liu et al.
Kaiwu Meng et al.
Background: The hemoglobin glycation index (HGI), quantifying interindividual hemoglobin glycation variability, predicts cardiovascular outcomes but lacks exploration in cerebrovascular prognosis. We evaluated its nonline...
FAM111B as a biomarker influences the prognosis and immune microenvironment of low-grade gliomas [0.03%]
FAM111B作为生物标志物影响低级别胶质瘤的预后和免疫微环境
Shuang Chen,Zhendong Liu,Yanzheng Gao
Shuang Chen
Background: In recent years, FAM111B has been found to be closely related to the occurrence and development of various cancers. However, the role of FAM111B in low-grade glioma (LGG) remains unclear. ...
Electroacupuncture activation of the CaMKII/CREB pathway improves dLGN synaptic plasticity in monocular deprivation amblyopic rats [0.03%]
电针激活CaMKII/CREB信号通路改善形觉剥夺性斜视动物丘脑可塑性研究
Chenying Hu,Lin Wang,Qinghong Li et al.
Chenying Hu et al.
Objective: This study aimed to investigate the therapeutic potential of electroacupuncture(EA) for amblyopia, a common childhood visual disorder caused by early abnormalities such as monocular deprivation(MD). We examined...
Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury [0.03%]
脑缺血再灌注损伤中Cortexin通过调节OPG/RANK/RANKL及TRPC1表达发挥作用
Cengiz Guven,Ahmet Türk,Seda Koçak et al.
Cengiz Guven et al.
Objective: Biomarkers such as Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor κ-B (RANK), its ligand RANKL, and Transient Receptor Potential Canonical 1 (TRPC1) have been implicated in the neuroprotective res...
Nitroglycerin attenuates ischemic neuronal injury via PKG-dependent regulation of endoplasmic reticulum (ER) stress and glucose metabolism [0.03%]
nitroglycerin通过PKG依赖性调节内质网(ER)应激和糖代谢来减轻缺血性神经元损伤
Hongrui Wang,Shangqian Jiang,Yuchuan Ding et al.
Hongrui Wang et al.
Background: Nitroglycerin (GTN), a widely used anti-anginal drug, has emerged as a potential alternative therapy for acute ischemic stroke. However, the underlying protective mechanisms of GTN in neuronal ischemic injury ...
Diagnostic efficacy of multimodal MRI combined with ICAM-1 for cognitive impairment after intracerebral hemorrhage [0.03%]
结合多模态MRI及ICAM-1诊断颅内出血后认知障碍的效能
Hongxiang Fu,Lixin Luo,Li Chen
Hongxiang Fu
Objective: We aimed to investigate the diagnostic value of multimodal magnetic resonance imaging (MRI) combined with intercellular adhesion molecule-1 (ICAM-1) in detecting cognitive impairment (CI) after intracerebral he...
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice [0.03%]
Celastrol治疗可减轻阿尔茨海默病模型小鼠的炎症反应
Fanfan Cao,Pan Zhang,Zelun Zheng et al.
Fanfan Cao et al.
Objective: Alzheimer's disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited, and thus, the discovery of novel anti-AD agents is urgently needed. Celas...
Relationship between cerebrospinal fluid catecholamines levels and biomarkers of Alzheimer's disease, inflammation and neuronal injury [0.03%]
脑脊液中肾上腺素类水平与阿尔茨海默病、炎症及神经元损伤生物标志物之间的关系
Isabel Portela Moreira,Paula Serrão,Lucinda Sequeira et al.
Isabel Portela Moreira et al.
Objectives: Changes in the locus coeruleus are among the earliest events in Alzheimer's disease (AD). We aimed to evaluate the relationship between cerebrospinal fluid (CSF) L-dihydroxyphenylalanine (L-DOPA), dopamine, an...
Low mean platelet volume: a risk factor for increased intraoperative blood loss in degenerative lumbar surgery [0.03%]
平均血小板体积偏低：退变性腰椎手术中术中出血增多的风险因素
Ehsan Alimohammadi,Alireza Sadeghsalehi,Fatemeh Ranjbari et al.
Ehsan Alimohammadi et al.
Background: Major intraoperative blood loss (MIBL) is associated with increased morbidity and poorer outcomes. This study investigates whether preoperative mean platelet volume (MPV) may serve as a predictive biomarker fo...