A prediction model of silent brain infarction constructed based on ultrasonic features of carotid plaques and resistance of intracranial blood flow [0.03%]
基于颅内血流阻力和颈动脉斑块声学特征的静息性脑梗死预测模型研究
Congxin Chen,Yurong Ge,Quanlong Hong et al.
Congxin Chen et al.
Objective: We aimed to construct a prediction model of silent brain infarction (SBI) based on ultrasonic features of carotid plaques and resistance of intracranial blood flow. ...
Exploration of circadian rhythm characteristics and its impact on prognosis and neuroinflammation in acute ischemic stroke patients [0.03%]
缺血性卒中患者昼夜节律特征及其对预后和神经炎症影响的探讨
Qian Sun,Cheng-Wei Guo,Sheng-Nan Chen et al.
Qian Sun et al.
Objective: This study evaluated endogenous circadian rhythm characteristics in mild acute ischemic stroke (AIS) patients, their impact on prognosis, and underlying mechanisms. ...
Comprehensive neurointervention training and service capacity in the Middle East & North Africa (NITA-MENA) study [0.03%]
中东和北非综合神经介入培训与服务能力研究(NITA-MENA)
Ossama Yassin Mansour,Seon Kyu Lee,Violiza Inoa et al.
Ossama Yassin Mansour et al.
Objective: The Middle East and North Africa (MENA) region faces a critical neurointervention workforce shortage, with an estimated 115,000-130000 preventable deaths annually from treatable neurovascular conditions. We qua...
Serum biomarkers sE-selectin and CCL5: indicators of postoperative delayed cerebral edema in hypertensive intracerebral hemorrhage [0.03%]
血浆生物标志物sE-选择素和CCL5在高血压脑出血手术后脑水肿中的意义研究
Chenjia Gui,Shunde Liu,Lijin He et al.
Chenjia Gui et al.
Objective: This investigation assessed the predictive value of serum soluble E-selectin (sE-selectin) and C motif chemokine ligand 5 (CCL5) for delayed cerebral edema (DCE) following hematoma removal in patients with hype...
Melatonin attenuates neurovascular unit dysfunction via AKT/GSK-3β/CREB pathway in hypoxic-ischemic neonatal rats [0.03%]
褪黑素通过Akt/GSK-3β/CREB信号途径减轻缺氧缺血性脑损伤新生大鼠神经血管单元功能障碍
Chenmeng Liu,Miao Yu,Yijing Wang et al.
Chenmeng Liu et al.
Objectives: Previous research has shown that melatonin (Mel) can alleviate hypoxic-ischemic brain damage (HIBD) in newborns. The roles of Mel on neurovascular unit (NVU) after HIBD and the mechanisms were explored in this...
A pilot cohort study of feasibility and safety of early passive upright positioning for neurocritically ill patients [0.03%]
神经重症患者早期被动直立位姿势的可行性与安全性试点队列研究
Geng Jia,Zhenwei Liu,Changchun Yang et al.
Geng Jia et al.
Objectives: To evaluate the feasibility and safety of passive upright positioning (PUP) using a standing bed in neurocritically ill patients. Methods: ...
Association between herpes simplex virus type 2 infection and 1-year risk of ischemic stroke recurrence: a prospective cohort study [0.03%]
人疱疹病毒2型感染与缺血性卒中复发风险的关系：一项基于前瞻性队列研究的荟萃分析
Ling Hu,Ming Wei,Yanfeng Wang et al.
Ling Hu et al.
Objective: To investigate the association between herpes simplex virus type 2 (HSV-2) infection and 12-month recurrence of acute ischemic stroke (AIS). Me...
Spinal astrocytic EAATs mediate endothelin-1-induced breakthrough cancer pain in mice [0.03%]
小鼠脊髓星形胶质细胞中的EAAT介导癌痛爆发的机制研究
Siqing Jiang,Dong Huang,Lihua Huang et al.
Siqing Jiang et al.
Background: Breakthrough cancer pain (BTcP) lacks representative animal models. The roles of spinal excitatory amino acid transporters (EAATs) in BTcP remain unclear. ...
Study on the mechanism of TMZ resistance in brain glioma regulated by copper death [0.03%]
铜死亡介导的胶质瘤TMZ耐药机制研究
Yabo Sun,Abudula Aisha,Yufei Qu et al.
Yabo Sun et al.
Purpose: The objective of this study is to investigate the mechanism of cuproptosis regulation in TMZ resistance in GBM, and provide an important theoretical basis for the rational design of combination therapy to block T...
Metformin attenuates PTZ-Induced seizures and cognitive impairment and is associated with altered NOS/NO signaling: combined in vivo and in silico evidence [0.03%]
二甲双胍通过抑制NOS/NO信号通路改变削弱戊四唑诱导的癫痫发作和认知障碍：体内与体外联合证据
Arzuhan Çetindağ Çiltaş,Bilal Şahin,Levent Hacisüleyman
Arzuhan Çetindağ Çiltaş
Background: Epilepsy remains a major neurological disorder with high rates of drug resistance and cognitive decline. Repurposing neuroprotective drugs offers a promising approach. Metformin, a widely used antidiabetic age...