Gender-dependent differences in the incidence of ochratoxin A-induced neural tube defects in the Pdn/Pdn mouse [0.03%]
赭曲霉毒素A致Pdn/Pdn小鼠神经管畸形的性别差异发生率
Etsuko Ueta,Mami Kodama,Yoshiki Sumino et al.
Etsuko Ueta et al.
Genetic polydactyly/arhinencephaly mouse embryo, Pdn/Pdn, exhibits suppression of Gli3 gene expression. Ochratoxin A (OTA) is a teratogen that causes neural tube defects (NTD) in mice. We investigated gender-dependent differences in the inc...
Biochemical alterations in the palatal processes in fetuses of biotin-deficient mice [0.03%]
生物素缺乏小鼠胎仔腭突变化的生化机制研究
Toshiaki Watanabe,Ai Suzuki,Shuhei Ebara et al.
Toshiaki Watanabe et al.
To clarify the role of biotin in palatal formation, we investigated the effects of biotin deficiency on the development of palatal processes in mouse fetuses at midgestation. We also investigated protein expressions in the palatal processes...
No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control study [0.03%]
一项基于人群的病例对照研究：孕妇严重的便秘及其相关的药物治疗与后代先天性畸形无关联
Nándor Acs,Ferenc Bánhidy,Erzsébet H Puhó et al.
Nándor Acs et al.
Constipation is a common pathological condition in pregnant women; nevertheless, its possible association with structural birth defects (i.e. congenital abnormalities [CA]) in their offspring has not been studied in controlled epidemiologic...
Birth defects caused by mutations in human GLI3 and mouse Gli3 genes [0.03%]
人类GLI3和小鼠Gli3基因突变引起的出生缺陷
Ichiro Naruse,Etsuko Ueta,Yoshiki Sumino et al.
Ichiro Naruse et al.
ABSTRACT GLI3 is the gene responsible for Greig cephalopolysyndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS) and Postaxial polydactyly type-A (PAP-A). Genetic polydactyly mice such as Pdn/Pdn (Polydactyly Nagoya), Xt(H)/Xt(H) (Extra...
Epigenetic abnormality of SRY gene in the adult XY female with pericentric inversion of the Y chromosome [0.03%]
性染色体臂间倒位的成年XY女性中SRY基因表观异常研究
Tomoko Mitsuhashi,Katsuhiko Warita,Teruo Sugawara et al.
Tomoko Mitsuhashi et al.
In normal ontogenetic development, the expression of the sex-determining region of the Y chromosome (SRY) gene, involved in the first step of male sex differentiation, is spatiotemporally regulated in an elaborate fashion. SRY is expressed ...
Congenital abnormalities in the offspring of pregnant women with type 1, type 2 and gestational diabetes mellitus: a population-based case-control study [0.03%]
1型、2型和妊娠糖尿病母亲的子代先天畸形的病例对照研究
Ferenc Bánhidy,Nándor Acs,Erzsébet H Puhó et al.
Ferenc Bánhidy et al.
To estimate the risk of structural birth defects (i.e. congenital abnormalities [CA]) in the offspring of pregnant women with type 1 (DM-1), type 2 (DM-2) and gestational diabetes mellitus (GDM) and to check the efficacy of recent specific ...
Teratogenic potential of pholedrine: a sympathomimetic vasoconstrictive drug - a population-based case-control study [0.03%]
苯甲醇的致畸可能性：基于人口的病例对照研究
Ferenc Bánhidy,Nándor Acs,Erzsébet H Puhó et al.
Ferenc Bánhidy et al.
Pholedrine was a frequently used drug for the treatment of severe hypotension in some countries, including Hungary. The possible teratogenic effect of pholedrine was not checked; therefore; the birth outcomes, particularly congenital abnorm...
Alteration in anxiety-related behaviors and reduction of serotonergic neurons in raphe nuclei in adult rats prenatally exposed to ethanol [0.03%]
孕期酒精暴露大鼠成年后海马及相关脑区5-HT神经元减少及焦虑样行为改变
Ken-ichi Ohta,Hiromi Sakata-Haga,Yoshihiro Fukui
Ken-ichi Ohta
It is known that the developing serotonergic system is one of the targets of ethanol teratogenicity. Because serotonin has multiple functions in both mature and immature brains, disturbance of the serotonergic system by ethanol exposure in ...
Brachmann-de Lange syndrome with congenital diaphragmatic hernia and NIPBL gene mutation [0.03%]
合并先天性膈疝和NIPBL基因突变的布拉赫曼-德兰热综合征
Shinichi Hosokawa,Nobumasa Takahashi,Hiroyuki Kitajima et al.
Shinichi Hosokawa et al.
We report herein a case of Brachmann-de Lange syndrome complicated with congenital diaphragmatic hernia in which a NIPBL gene mutation was identified. A female infant born at 37 weeks of gestation died 134 min after delivery, even though en...
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion [0.03%]
2,3,7,8-四氯二苯并对二噁英的效应提示腭融合后的腭发育异常
Hideto Imura,Tomohiro Yamada,Katsuaki Mishima et al.
Hideto Imura et al.
Mouse embryos exposed to 2,3,7,8-tetrachloridedibenzo-p-dioxin (TCDD) develop cleft palates and hydronephrosis. Cleft palates occur after TCDD exposure due to contact and/or fusion failure. We investigated whether cleft palate can be induce...