Eriko Simamura,Hiroki Shimada,Hiroki Shoji et al.
Eriko Simamura et al.
Melanocortins, adrenocorticotropic hormone (ACTH) and α-, β-, and γ-melanocyte-stimulating hormone (MSH) are produced in the placenta and secreted into embryos/fetuses. ACTH concentrations are higher in fetal plasma than in maternal plas...
Role of rare cases in deciphering the mechanisms of congenital anomalies: CHARGE syndrome research [0.03%]
罕见病例在解码先天畸形机制中的作用：CHARGE综合征研究
Kenjiro Kosaki
Kenjiro Kosaki
In this review, our work on CHARGE syndrome will be used to exemplify the role of rare cases in birth defects research. The analysis of 29 cases with mutations of CHD7, the causative gene for CHARGE syndrome, clarified the relative importan...
Message from the Editor-in-Chief [0.03%]
主编寄语
Yuji Nakajima
Yuji Nakajima
Analysis of genitourinary anomalies in patients with VACTERL (Vertebral anomalies, Anal atresia, Cardiac malformations, Tracheo-Esophageal fistula, Renal anomalies, Limb abnormalities) association [0.03%]
VACTERL（椎体异常、肛门闭锁、心脏畸形、气管食管瘘、肾异常、肢体异常）相关患者的泌尿生殖系统异常分析
Benjamin D Solomon,Manu S Raam,Daniel E Pineda-Alvarez
Benjamin D Solomon
The goal of this study was to describe a novel pattern of genitourinary (GU) anomalies in VACTERL association,which involves congenital anomalies affecting the vertebrae,anus, heart, trachea and esophagus, kidneys, and limbs.We collected cl...
Adrenocorticotropic tumor cells transplanted into mouse embryos affect pancreatic histogenesis [0.03%]
促肾上腺皮质激素肿瘤细胞移植对小鼠胚胎胰腺组织发生的影响
Mai Kawamoto,Jun Udagawa,Ryuju Hashimoto et al.
Mai Kawamoto et al.
A wide range of individual differences exist in the total number of functional and structural units in each organ, such as β cells in pancreatic islands, and these units are the basis of the organ's overall function, including its function...
Paul A L Lancaster
Paul A L Lancaster
Environmental causes of birth defects have increasingly been recognized since the mid-20th century. The teratogenic effects of maternal infections such as rubella and therapeutic drugs such as thalidomide were first reported by alert clinic...
Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens [0.03%]
小型队列研究识别新致畸物的价值：包括体格检查以发现轻微畸形的价值评估
Christina D Chambers
Christina D Chambers
Most known human teratogens are associated with a unique or characteristic pattern of major and minor malformations and this pattern helps to establish the causal link between the teratogenic exposure and the outcome. Although traditional c...
Drug safety in pregnancy: utopia or achievable prospect? Risk information, risk research and advocacy in Teratology Information Services [0.03%]
孕期药物安全性：乌托邦还是可实现的前景？毒理信息服务中的风险信息、风险研究和倡导作用
Christof Schaefer
Christof Schaefer
Even though from preclinical testing to drug risk labeling, the situation with drugs in pregnancy has improved substantially since the thalidomide scandal, there is still an increasing need to provide healthcare professionals and patients w...
In vitro models of pancreatic differentiation using embryonic stem or induced pluripotent stem cells [0.03%]
利用胚胎干细胞或诱导多能干细胞的体外胰腺分化模型
Yuichiro Higuchi,Nobuaki Shiraki,Shoen Kume
Yuichiro Higuchi
Embryonic stem (ES) cells or induced pluripotent stem (iPS) cells are expected as a surrogate cell source for regenerative medicine. Many researchers have reported the differentiation method of insulin-expressing pancreatic β cells from ES...
Nilgün Kanlıoğlu Kuman,Serdar Sen,Ekrem Sentürk et al.
Nilgün Kanlıoğlu Kuman et al.