Traditional chinese medicine-based network pharmacology could lead to new multicompound drug discovery [0.03%]
基于中医药的网络药理学有可能引领多组分药物新发现
Jian Li,Cheng Lu,Miao Jiang et al.
Jian Li et al.
Current strategies for drug discovery have reached a bottleneck where the paradigm is generally "one gene, one drug, one disease." However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. ...
Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia morrisonensis Hayata in Mice [0.03%]
艾纳香醇提物的镇痛抗炎作用研究
Shen-Chieh Chou,Yung-Jia Chiu,Chao-Jung Chen et al.
Shen-Chieh Chou et al.
The aim of this study was to investigate the possible analgesic and anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AM(EtOH)). Two models were employed for evaluation of the analgesic effects: acetic acid-i...
Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice [0.03%]
hochuekkito(TJ-41)能改善由结肠26腺癌诱导的小鼠恶病质
Suzu Yae,Fumiyuki Takahashi,Toshifumi Yae et al.
Suzu Yae et al.
Cachexia, a major cause of cancer-related death, is characterized by depletion of muscle and fat tissues, anorexia, asthenia, and hypoglycemia. Recent studies indicate that secretions of proinflammatory cytokines such as interleukin-6 (IL-6...
Wen Zou,Ying Liu,Jian Wang et al.
Wen Zou et al.
To assess the effects of TCHM on patients with HIV infection and AIDS, we reviewed eleven randomized placebo-controlled trials involving 998 patients. Due to the limited number of RCTs for included trials and the small sample size of each s...
Partly Separated Activations in the Spatial Distribution between de-qi and Sharp Pain during Acupuncture Stimulation: An fMRI-Based Study [0.03%]
针刺过程中得气与锐痛感之间空间分布的激活分离性：基于fMRI的研究
Jinbo Sun,Yuanqiang Zhu,Lingmin Jin et al.
Jinbo Sun et al.
Nowadays, functional magnetic resonance imaging (fMRI) has become one of the most important ways to explore the central mechanism of acupuncture. Among these studies, activations around the somatosensory-related brain network had the most r...
Herbal Compound "Songyou Yin" Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness [0.03%]
复方中药“松友饮”通过抑制肝癌干性增强其对奥沙利铂的敏感性
Qing-An Jia,Zheng-Gang Ren,Yang Bu et al.
Qing-An Jia et al.
We investigated the effect of Chinese herbal compound Song-you Yin on HCC stemness. MHCC97H and Hep3B cell lines were pretreated with SYY for 4 weeks, and their chemosensitivity to oxaliplatin was evaluated. The expression of CSC-related ma...
Curative effects of oleanolic Acid on formed hypertrophic scars in the rabbit ear model [0.03%]
熊果酸治疗兔耳增生性瘢痕的疗效研究
Hong Zhang,Yan Zhang,Yi-Ping Jiang et al.
Hong Zhang et al.
Hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ECM). There is no consensus about the best therapeutics to produce com...
Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice [0.03%]
饮食中的藏红花素抑制雄性ICR小鼠的结肠炎和结肠炎相关结直肠癌发生率
Kunihiro Kawabata,Nguyen Huu Tung,Yukihiro Shoyama et al.
Kunihiro Kawabata et al.
A natural carotenoid crocin is contained in saffron and gardenia flowers (crocuses and gardenias) and is used as a food colorant. This study reports the potential inhibitory effects of crocin against inflammation-associated mouse colon carc...
Lorna Kwai-Ping Suen,Yuk-Kong Lau,Hok-Cheung Ma et al.
Lorna Kwai-Ping Suen et al.
The ear has a reflexive property; therefore, various physical attributes may appear on the auricle when disorders of the internal organs or other parts of the body exist. Auricular diagnostics is an objective, painless, and noninvasive meth...
Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy [0.03%]
罗帝洛林诱导的癌细胞死亡的替代途径：凋亡与自噬
Claudia Torricelli,Sara Salvadori,Giuseppe Valacchi et al.
Claudia Torricelli et al.
Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyp...