The effect of dosage, gestational age and splenectomy on anti-IgM interception of prenatal B-cell development in sheep [0.03%]
剂量、妊娠时间和脾切除对羊胎儿B细胞发育的抗IgM拦截的影响
P McCullagh,C McL Press,S J McClure et al.
P McCullagh et al.
The administration of a single bolus of anti-IgM antibody to foetal lambs early in pregnancy produces prolonged B-cell depletion. The present study investigated this depletion by examining the effect, on B-cell development in the ileal Peye...
CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation [0.03%]
CTLA-4诱导的T细胞共刺激信号抑制Th2但不抑制Th1极化反应
Vanessa Ubaldi,Lucia Gatta,Luigia Pace et al.
Vanessa Ubaldi et al.
CTLA-4 deficient mice show severe lymphoproliferative disorders with T helper sub-population skewed toward the Th2 phenotype. In the present work, we investigated the role of CTLA-4 in T helper cell subset differentiation. Naïve CD4+ cells...
Philipp Ströbel,Tobias Preisshofen,Markus Helmreich et al.
Philipp Ströbel et al.
Thymic T cell development is characterized by sequential selection processes to ensure generation of a self-tolerant, immuncompetent mature T cell repertoire. Malfunction of any of these selection processes may potentially result in either ...
Adam F Cunningham,Kai-Michael Toellner
Adam F Cunningham
The paradigm of T helper-1 (Th-1) and Th-2 cells developing from non-committed naive precursors is firmly established. Th1 cells are characterized by IFNgamma production and, in mice, the selective switching to IgG2a. Conversely IL-4 produc...