A review of the physiological and immunological functions of biliary epithelial cells: targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias [0.03%]
胆道上皮细胞的生理和免疫功能的综述：原发性胆汁性肝硬化，原发性硬化性胆管炎和药物性胆管损伤的作用靶点
Chih-Te Wu,Paul A Davis,Velimir A Luketic et al.
Chih-Te Wu et al.
Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules...
Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis? [0.03%]
炎症性肠病：自身免疫性疾病还是免疫介导性疾病？
Zhonghui Wen,Claudio Fiocchi
Zhonghui Wen
The pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), is still unclear, but both autoimmune and immune-mediated phenomena are involved. Autoimmune phenomena include the...
On the mechanisms of the protective effect of infections on type 1 diabetes [0.03%]
感染对1型糖尿病保护作用的机制研究进展
Hélène Feillet,Jean-François Bach
Hélène Feillet
The incidence of type 1 diabetes (T1D) shows a worrying tendency for a steady increase in Western countries. Along the line of the hygiene hypothesis, evidence accumulates to suggest that this increase is explained by the decrease of infect...
Matthias Wjst
Matthias Wjst
The early induction of allergy is a complex process involving protective and destructive gene variants, environmental and nutritional co-factors as well as allergen exposure. Although critical doses, interactions and susceptible time frames...
Paul Ashwood,Judy Van de Water
Paul Ashwood
Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes [0.03%]
harbour seal ( Phoca vitulina)淋巴细胞蛋白激酶cDNA的克隆与测序
Jennifer C C Neale,Thomas P Kenny,M Eric Gershwin
Jennifer C C Neale
Protein kinases (PKs) play critical roles in signal transduction and activation of lymphocytes. The identification of PK genes provides a tool for understanding mechanisms of immunotoxic xenobiotics. As part of a larger study investigating ...
Dialectics and implications of natural neurotropic autoantibodies in neurological disease and rehabilitation [0.03%]
自然神经导向自体抗体在神经疾病与康复中的辩证及影响学派
A B Poletaev,A A Abrosimova,M A Sokolov et al.
A B Poletaev et al.
The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuroantigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided co...
Inhibition of IL-1beta and TNF-alpha secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S [0.03%]
TraumeelS对静息和活化的免疫细胞分泌白细胞介素-1β和肿瘤坏死因子-α的抑制作用
Svetlana Porozov,Liora Cahalon,Michael Weiser et al.
Svetlana Porozov et al.
Traumeel S (Traumeel), a mixture of highly diluted (10(-1)-10(-9)) extracts from medicinal plants and minerals is widely used in humans to relieve trauma, inflammation and degenerative processes. However, little is known about its possible ...
Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus [0.03%]
稳态新生小鼠胸腺中αEβ7与E-钙黏蛋白相互作用的功能研究
Susan E Prockop,Howard T Petrie
Susan E Prockop
T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex. Here, we show that despite alphaEbeta7 expression by a subset of the earliest intrathy...
Serial analysis of antimitochondrial antibody in patients with primary biliary cirrhosis [0.03%]
原发性胆汁性肝硬化的抗线粒体抗体的系列分析
Gordon D Benson,Kentaro Kikuchi,Hiroshi Miyakawa et al.
Gordon D Benson et al.
Antimitochondrial antibodies (AMAs) are the classic serologic marker in primary biliary cirrhosis (PBC). However, there have been only limited attempts to study changes in titer or isotype analysis of such AMAs in patients followed for long...