Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease [0.03%]
预脉冲抑制：精神病学领域的新进展
Hidetoshi Takahashi,Ryota Hashimoto,Masao Iwase et al.
Hidetoshi Takahashi et al.
Prepulse inhibition (PPI) is considered to be one of the most promising neurophysiological indexes for translational research in psychiatry. Impairment of PPI has been reported in several psychiatric diseases, particularly schizophrenia, wh...
No Association between the Response to the Addition of an Atypical Antipsychotic Drug to an SSRI or SNRI and the BDNF (Val66Met) Polymorphism in Refractory Major Depressive Disorder in Japanese Patients [0.03%]
日裔难治性抑郁症患者中，BDNF（Val66Met）多态性和SSRI或SNRI联用非典型抗精神病药反应无相关性
Reiji Yoshimura,Taro Kishi,Hikaru Hori et al.
Reiji Yoshimura et al.
Objective: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reupt...
Aripiprazole Improved Obsessive Compulsive Symptoms in Asperger's Disorder [0.03%]
阿立哌唑可改善阿斯伯格综合征患者的强迫症状
Gonca Celik,Aysegul Yolga Tahiroglu,Sunay Firat et al.
Gonca Celik et al.
There are many comorbid disorders associated with autism spectrum disorders in child and adolescent population. Although obsessive compulsive disorder and autism spectrum disorders (ASD) comorbidity has common in clinical practice, there ar...
Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimer's Disease [0.03%]
基因变异谱作为阿尔茨海默病早期诊断潜在无创生物标志物的可能性研究
Suk Ling Ma,Linda Chiu Wa Lam
Suk Ling Ma
Alzheimer's disease (AD) is the most prevalent form of dementia. Biomarkers such as levels of amyloid beta (Aβ) in cerebrospinal fluid and ApoE genotyping were suggested for the diagnosis of AD, however, the result is either non-conclusive...
In Vivo Evaluation of (11)C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse Brain [0.03%]
三种甘氨酸转运蛋白1放射配体的体内评价研究报告
Ji-Chun Zhang,Jun Toyohara,Jin Wu et al.
Ji-Chun Zhang et al.
Objective: Glycine transporter 1 (GlyT-1) is one of the most attractive therapeutic targets for schizophrenia. There is great interest in developing radioligands for in vivo imaging of GlyT-1 in the brain using positron e...
Second-generation antipsychotic discontinuation in first episode psychosis: an updated review [0.03%]
首发精神病患者的第二代抗精神病药停药机制的最新综述
Brian J Miller,Chelsea Bodenheimer,Krystle Crittenden
Brian J Miller
"All-causes discontinuation" refers to discontinuation of treatment for any reason, and medication adherence is an important component of this measure. Similar to our previous results, we found that almost 30% of patients with first-episode...
Long-term Escitalopram Treatment in Korean Patients with Panic Disorder: A Prospective, Naturalistic, Open-label, Multicenter Trial [0.03%]
韩国惊恐障碍患者长期服用艾司西酞普兰的疗效和安全性：一项多中心开放研究
Kwan-Woo Choi,Jong-Min Woo,Youl-Ri Kim et al.
Kwan-Woo Choi et al.
Objective: Panic disorder is characterized by recurrent panic attacks, persistent concerns about additional attacks, and worry about the implications of the attack or significant changes in behavior related to the attacks...
Effects of sinapic Acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat [0.03%]
芥子酸对四血管阻断模型所致大鼠缺血和认知障碍的影响
Young-Ock Kim,Sang-Won Lee,Myung-Sook Oh et al.
Young-Ock Kim et al.
Objective: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sina...
Are cardiometabolic and endocrine abnormalities linked to sleep difficulties in schizophrenia? A hypothesis driven review [0.03%]
精神分裂症的睡眠障碍与心血管代謝及內分泌異常有关吗？基于假说的文献回顾
Rébecca Robillard,Naomi L Rogers,Bradley G Whitwell et al.
Rébecca Robillard et al.
Schizophrenia is a psychiatric disorder that includes symptoms such as hallucinations, disordered thoughts, disorganized or catatonic behaviour, cognitive dysfunction and sleep-wake disturbance. In addition to these symptoms, cardiometaboli...
Rapid changes in d1 and d2 dopamine receptor binding in striatal subregions after a single dose of phencyclidine [0.03%]
一次潘克利定给药后纹状体内不同区域d1和d2多巴胺受体结合位点的快速变化
Victoria S Dalton,Katerina Zavitsanou
Victoria S Dalton
Objective: In humans, a single exposure to phencyclidine (PCP) can induce a schizophrenia-like psychosis which can persist for up to two weeks. In rats, an acute dose of PCP increases dopaminergic activity and causes chan...