Chinese herbal medicine and acupuncture reduce mortality after intracerebral hemorrhage [0.03%]
中药和针灸可降低脑出血后的死亡率
Dai-Ying Lin,Ming-Jen Wang,Ying-Hsiu Shih et al.
Dai-Ying Lin et al.
Background: Intracerebral hemorrhage (ICH) is the second most common stroke worldwide and is associated with high mortality rates. Despite established guidelines for ICH treatment, the prognosis of ICH remains poor. Tradi...
Different aflibercept regimens for wet age-related macular degeneration: A systematic review and network meta-analysis [0.03%]
阿柏西普治疗湿性年龄相关性黄斑变性疾病的不同方案：系统评价和网状Meta分析
Yu-Sheng Chen,Hua-Ching Chang,Sheng-Chu Chi et al.
Yu-Sheng Chen et al.
Background: Intravitreal aflibercept injection for wet age-related macular degeneration (AMD) was initially approved with a regimen consisting of three monthly loading doses followed by maintenance doses every 8 weeks. Al...
Comprehensive review of current management and precision medicine in pancreatic cancer [0.03%]
胰腺癌综合诊疗及精准医疗进展的全面回顾
Hung-Yuan Yu,Le-Gin Lin,Yee Chao et al.
Hung-Yuan Yu et al.
Pancreatic cancer is one of the most lethal malignancies, with an increasing incidence and limited improvement in survival despite therapeutic advances. Surgical resection remains the only curative option; however, recurrence is frequent, a...
Causal links of 233 metabolic markers to benign prostatic hyperplasia: Mendelian randomization and RNA- sequencing insights [0.03%]
233种代谢标志物与良性前列腺增生的因果关系：孟德尔随机化和RNA测序研究见解
Pengfei Zhou,Zaisheng Zhu
Pengfei Zhou
Background: Benign prostatic hyperplasia (BPH) is a common urological condition affecting middle-aged and elderly men, and it significantly impairs their quality of life. Although metabolic disorders are suspected to cont...
Clinical presentations and prognostication of HER2-low and HER2-zero early breast cancer in Taiwan [0.03%]
台湾HER2低表达和HER2阴性早期乳腺癌的临床特征及预后分析
Yen-Jen Chen,Pei-Ju Lien,Ling-Ming Tseng et al.
Yen-Jen Chen et al.
Background: Human epidermal growth factor receptor II (HER2)low breast cancer has emerged as a clinically relevant subset of HER2‑negative disease, but its prognostic significance in early‑stage, real‑world populations...
Chia-Hsien Wu,Hsueh-An Sun,Heng-Jui Hsu
Chia-Hsien Wu
Background: Parotidectomy, the surgical excision of the parotid gland to treat tumors, is frequently complicated by sialocele formation-a subcutaneous accumulation of saliva that presents clinically as a cystic mass. With...
Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine [0.03%]
超越疾病的治疗与预防：从衰老科学和分子标志到抗衰药物及精准防老医学
Li-Ning Peng,Fei-Yuan Hsiao,Liang-Kung Chen
Li-Ning Peng
Geroscience - the interdisciplinary field investigating the causal relationship between the biology of aging and age-related chronic disease - has undergone a remarkable evolution since its formalization within the United States National In...
An in trans NOTCH3 loss-of-function variant modifies disease severity in CADASIL: A family-based study [0.03%]
NOTCH3失活变异通过家族研究影响CADASIL的疾病严重程度
Shih-Chun Lan,Yi-Hong Liu,Jui Lan et al.
Shih-Chun Lan et al.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by pathogenic NOTCH3 variants, most commonly heterozygous cysteine-altering variants. Disease seve...
Proposed study design for estimating COVID-19 vaccine effectiveness in post-pandemic Taiwan [0.03%]
后疫情时代台湾COVID-19疫苗效力估计之研究设计构想
Long-Sheng Chen,Cheng-Yi Lee,Hung-Wei Kuo et al.
Long-Sheng Chen et al.
Post-licensure observational studies are used to assess vaccine effectiveness (VE) when clinical randomized controlled trials are not feasible. Although vaccination engenders various effects at the individual and population levels, few stud...