Prophylaxis of bleeding episodes and surgical interventions in patients with rare inherited coagulation disorders [0.03%]
罕见遗传性凝血障碍患者的出血发作和手术干预的预防措施
Giancarlo Castaman
Giancarlo Castaman
Rare inherited coagulation disorders (RICD) represent a group of inherited deficiencies of clotting factors characterized by a low prevalence in the general population (usually around 1:1,000,000 inhabitants) and, in severe cases (homozygou...
Surgical prophylaxis in von Willebrand's disease: a difficult balance to manage [0.03%]
韦尔德兰病的手术预防：一个难以把握的平衡点
Massimo Franchini
Massimo Franchini
Von Willebrand disease (VWD) is the most common genetic bleeding disorder with a prevalence of approximately 1-2 percent confirmed in different population studies. The severity of the bleeding tendency is usually proportional to the degree ...
Prophylaxis of bleeding episodes in patients with von Willebrand's disease [0.03%]
血管性血友病患者出血发作的预防治疗
Augusto B Federici
Augusto B Federici
Patients with severe forms of von Willebrand's disease (VWD) may have frequent haemarthroses, especially when factor VIII (FVIII) levels are below 10 U/dL, so that some of them develop target joints like patients with severe haemophilia A. ...
Secondary prophylaxis with factor IX concentrates: continuous infusion [0.03%]
第九因子持续性静脉滴注用于乙型血友病反复关节出血的预防治疗
Massimo Morfini
Massimo Morfini
Haemophilia patients may require prolonged treatment during peri-operative period or life-threatening bleedings. Intermittent bolus infusions of factor concentrates have been used successfully for many years. However, pharmacokinetics may v...
Annarita Tagliaferri,Caterina Di Perna,Gianna Franca Rivolta
Annarita Tagliaferri
Progressive arthropathy of large joints of the limbs (knees, ankles, elbows), resulting from recurrent joint bleeds and subsequent long-term degenerative phenomena, is one of the main causes of morbidity and of deterioration of quality of l...
Barriers to primary prophylaxis in haemophilic children: the issue of the venous access [0.03%]
血友病儿童一级预防静脉通路障碍问题探究
Elena Santagostino,Maria Elisa Mancuso
Elena Santagostino
Modem treatment for hemophilic children is based on prophylaxis and immune tolerance induction (ITI). Both treatment regimens are based on frequent infusions at early ages, therefore an adequate venous access is essential. Peripheral veins ...
Antonio Coppola,Mirko Di Capua,Ciro De Simone
Antonio Coppola
Starting from the clinical observations that moderate haemophiliacs experienced only few bleeding episodes and rarely developed significant joint deterioration (haemophilic arthropathy), and the pioneer experience in Sweden, prophylaxis (i....
Prophylaxis in congenital coagulation disorders: past, present and future [0.03%]
遗传性凝血障碍的预防治疗：过去、现在和未来展望
Pier Mannuccio Mannucci
Pier Mannuccio Mannucci
Anti-D immunisation with permanent biological damage following inadequate post-amniocentesis prophylaxis [0.03%]
羊水穿刺后预防措施不足导致的抗D免疫和永久性生物损害病例
Sisto Vecchio,Patrizia La Scala,Liliana Perri et al.
Sisto Vecchio et al.
Prospective study of the meaning of indeterminate results of the recombinant immunoblot assay for hepatitis C virus in blood donors [0.03%]
献血者使用丙型肝炎病毒重组免疫印迹检测试剂盒检测结果不确定者的临床意义的前瞻性研究
Loredana Piro,Stefano Solinas,Marina Luciani et al.
Loredana Piro et al.
Background: The interpretation of "indeterminate" results of the recombinant immunoblot assay (RIBA) is a particularly sensitive issue for Transfusion Services, and donors with such a serological condition require long-te...