A review of oral kallikrein inhibitor berotralstat for hereditary angioedema [0.03%]
口服 kalvikrein 抑制剂伯罗トラステ对遗传性血管水肿的疗效评价
YingYu Gao,Jacqueline Hwang,Gloria Hwang et al.
YingYu Gao et al.
Orladeyo, a once-daily oral formulation of berotralstat (formerly BCX-7353), is a novel oral small-molecule drug developed by BioCryst Pharmaceuticals for the prevention of hereditary angioedema (HAE) attacks. It was first approved by the U...
Giuseppe Cianciolo,Simona Barbuto,Francesca Iacovella et al.
Giuseppe Cianciolo et al.
Hyperphosphatemia is a common feature in patients with chronic kidney disease (CKD), especially in those with end-stage renal disease (ESRD). Commonly, high serum phosphate levels are observed only in later stages of CKD. The control of hyp...
Telitacicept, a novel humanized, recombinant TACI-Fc fusion protein, for the treatment of systemic lupus erythematosus [0.03%]
新型人源化重组TACI-FC融合蛋白telitacicept治疗系统性红斑狼疮
Yong Fan,Dai Gao,Zhuoli Zhang
Yong Fan
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, in which aberrant immune cells and proinflammatory mediators act as key players in the pathogenesis of the disease. Telitacicept (RC-18) is a novel, recombinant fusion prot...
Alberto Gajofatto,Riccardo Orlandi
Alberto Gajofatto
In recent years, B cells have been extensively studied as a therapeutic target in multiple sclerosis (MS). Particularly, anti-CD20 monoclonal antibodies (MAbs) such as rituximab or ocrelizumab have proven to be effective in treating various...
David M Paton
David M Paton
Estetrol (E₄) is a natural human estrogen produced during human pregnancy in the fetal liver with a unique mechanism of action that displays tissue-selective activity, and behaves as a natural selective estrogen receptor modulator. E₄ act...
American College of Rheumatology/Association of Rheumatology Professionals (ACR/ARP) 2021 Annual Meeting (November 5-9, 2021 - Virtual Meeting) [0.03%]
美国风湿病学会/风湿病专业协会(American College of Rheumatology/Association of Rheumatology Professionals，ACR/ARP)2021年年会(2021年11月5~9日)
M Spence
M Spence
ACR Convergence is the annual meeting of the American College of Rheumatology (ACR). This year, ACR Convergence was to be held in San Francisco, California, but due to the COVID-19 crisis and subsequent travel restrictions, it was changed t...
A Ianniello,C Pozzilli
A Ianniello
Ponesimod (ACT-128800) is a directly bioavailable, rapidly reversible sphingosine-1-phosphate (S1P) receptor modulator, highly selective for the subtype 1 (S1P₁ receptor). It acts by blocking the egress of lymphocytes from the lymphoid org...
Loncastuximab tesirine for diffuse large B-cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤患者接受Loncastuximab Tesirine治疗的安全性和有效性评估：2期临床研究结果
J Zurko,M Hamadani
J Zurko
Loncastuximab tesirine-lpyl (ADC Therapeutics), an anti-CD19 antibody-drug conjugate, was recently approved for the treatment of relapsed, refractory diffuse large B-cell lymphoma on the basis of the results of a phase II clinical trial, LO...
J Ho,S Molin
J Ho
Delgocitinib ointment is a newly approved topical medication for the treatment of atopic dermatitis (AD). AD usually has onset in early childhood and is a common, often chronic relapsing inflammatory skin condition that affects all age grou...
H Wilton-Clark,T Yokota
H Wilton-Clark
Duchenne muscular dystrophy (DMD) is a genetic disorder affecting 1 in 5,000 males which causes progressive muscle deterioration, loss of mobility and eventual death, with an average lifespan of around 25 years. While no cure currently exis...