Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies [0.03%]
氟西汀治疗难治性癫痫（德拉韦综合征及其他遗传性癫痫）
J Sullivan,R Simmons
J Sullivan
Fenfluramine hydrochloride, initially utilized as a weight loss drug in the 1970s and later removed from the market for adverse cardiopulmonary side effects, has since been repurposed as an antiseizure medicine (ASM). The potential antiseiz...
D Yardeni,C Koh
D Yardeni
Hepatitis B virus (HBV) and its satellite virus hepatitis D (HDV) are common worldwide hepatotrophic infections responsible for cirrhosis and hepatocellular carcinoma (HCC). The more common HBV infection has several therapeutic regimens cur...
A Blackmon,S O&#x;Brien
A Blackmon
Acalabrutinib was approved by the U.S. Food and Drug Administration (FDA) for treatment-naive (TN) and relapsed/refractory (R/R) use for patients with chronic lymphocytic leukemia (CLL) in November 2019 following the phase III ASCEND and EL...
M Colina
M Colina
The MedTech Forum 2021 was an online event at which participants from the field of medical devices, diagnostics and digital health openly shared their views on the latest trends, challenges and opportunities currently being faced. The event...
Onasemnogene abeparvovec-xioi: a gene replacement strategy for the treatment of infants diagnosed with spinal muscular atrophy [0.03%]
onasemnogeneabei-parvovec-xioi：脊髓性肌萎缩症婴儿患者的基因替代疗法
M Schwartz,S Likhite,K Meyer
M Schwartz
In May of 2019, the adeno-associated virus (AAV)-based gene therapy onasemnogene abeparvovec-xioi (Zolgensma) became the second Food and Drug Administration (FDA)-approved gene therapy with designated use for infants diagnosed with spinal m...
L Li,C Zou,S Dong et al.
L Li et al.
Small cell lung cancer (SCLC) is a rapidly progressive, aggressive metastatic and lethal subtype of lung cancer. Unfortunately, there has been little progress regarding the development of novel treatments for SCLC. However, lurbinectedin, a...
L Ielasi,V Sansone,A Forgione et al.
L Ielasi et al.
Hepatocellular carcinoma (HCC) is a worldwide problem, with a high prevalence in nonindustrialized countries and a rising incidence in industrialized countries. Its close association with chronic liver diseases and liver cirrhosis represent...
Pathophysiology of moderate to severe plaque psoriasis: anti-IL-17 towards disease modification [0.03%]
中重度斑块状银屑病的病理生理学：反 IL-17 以改变疾病进程
S Magina,P Filipe
S Magina
Psoriasis is a chronic inflammatory disease that can be triggered by injury, trauma, infection and medications. Genetic and immunologic studies have highlighted the importance of the interleukin (IL)-23/T-helper 17 (Th17) pathway in systemi...
D M Paton
D M Paton
The ultra-short-acting opioid analgesic remifentanil provided the approach that was used in the synthesis of remimazolam. A carboxylic ester was incorporated into the benzodiazepine structure providing a resultant compound that is rapidly b...
Inebilizumab in AQP4-Ab-positive neuromyelitis optica spectrum disorder [0.03%]
抗AQP4抗体阳性视神经脊髓炎谱系病患者中的Inebilizumab疗法
N Siebert,A Duchow,F Paul et al.
N Siebert et al.
Until recently, the use of preventative immunotherapy in neuromyelitis optica spectrum disorders (NMOSD) was based on observational studies and clinical experiences. Meanwhile, the first drugs, among others the monoclonal antibody inebilizu...