The effect of hypoxia on PGE2-stimulated cAMP generation in HMEC-1 [0.03%]
缺氧对PGE₂刺激的HMEC-1细胞内cAMP生成的影响研究
Anna Wiktorowska-Owczarek,Jacek Owczarek
Anna Wiktorowska-Owczarek
Prostaglandin E2 (PGE2) is generated in various cells, including endothelial cells, and is responsible for various functions, such as vascular relaxation and angiogenesis. Effects of PGE2 are mediated via receptors EP1-EP4, among which EP2 ...
Shuhei Yamada
Shuhei Yamada
Chondroitin sulfate (CS) is a ubiquitous component of the cell surface and extracellular matrix of animal tissues. CS chains are covalently bound to a core protein to form a proteoglycan, which is involved in various biological events inclu...
Biochemical evidence for Ca2+-independent functional activation of hPLSCR1 at low pH [0.03%]
低pH值独立于Ca2+激活hPLSCR1的功能的生化证据
Vincent Gerard Francis,Sathyanarayana N Gummadi
Vincent Gerard Francis
Human phospholipid scramblase 1 (hPLSCR1) is a Ca2+-dependent protein known to scramble phospholipids in the plasma membrane resulting in loss of membrane asymmetry. It has been reported that hPLSCR1 exhibits Ca2+- independent activity at l...
Generation of an efficient artificial promoter of bovine skeletal muscle α-actin gene (ACTA1) through addition of cis-acting element [0.03%]
通过添加顺式作用元件生成高效的牛骨骼肌α-actin基因（ACTA1）人工启动子
Qian Hu,Huili Tong,Dandan Zhao et al.
Qian Hu et al.
The promoter of skeletal muscle α-actin gene (ACTA1) is highly muscle specific. The core of the bovine ACTA1 promoter extends from +29 to -233, about 262 base pairs (bp), which is sufficient to activate transcription in bovine muscle satel...
Flow cytometric analysis of apoptosis in cryoconserved chicken primordial germ cells [0.03%]
基于流式细胞术的冷冻保存鸡原始生殖细胞凋亡分析
Dorota Sawicka,Luiza Chojnacka-Puchta,Marcin Zielinski et al.
Dorota Sawicka et al.
Our research aimed to compare the effects of four cryoprotectants and four slow freezing programs on the viability and apoptosis of primordial germ cells (PGCs) in vitro. PGCs were collected from chicken embryonic blood at Hamburger and Ham...
Changes in cell death of peripheral blood lymphocytes isolated from children with acute lymphoblastic leukemia upon stimulation with 7 Hz, 30 mT pulsed electromagnetic field [0.03%]
脉冲式电磁场（7Hz，30mT）刺激急性淋巴细胞白血病患儿外周血淋巴细胞的凋亡变化研究
Jolanta Kaszuba-Zwoińska,Magdalena Ćwiklińska,Walentyna Balwierz et al.
Jolanta Kaszuba-Zwoińska et al.
Pulsed electromagnetic field (PEMF) influenced the viability of proliferating in vitro peripheral blood mononuclear cells (PBMCs) isolated from Crohn's disease patients as well as acute myeloblastic leukemia (AML) patients by induction of c...
Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force - implications for studies on extracellular vesicles [0.03%]
强离心力下致癌基因依赖的癌细胞生存机制——对细胞外囊泡研究的影响
Tae Hoon Lee,Shilpa Chennakrishnaiah,Janusz Rak
Tae Hoon Lee
Extracellular vesicles (EVs), including exosomes, are a subject of intense interest due to their emission by cancer cells and role in intercellular communication. Earlier reports suggested that oncogenes, such as RAS, MET or EGFR, drive cel...
Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes [0.03%]
Lady Joy豆发酵粉对小鼠原代肝细胞的抗氧化作用
Margherita La Marca,Laura Pucci,Roberto Bollini et al.
Margherita La Marca et al.
The role and beneficial effects of plant and food extracts against various diseases induced by oxidative stress have received much attention in recent years. Legumes are rich in bioactive compounds, and some studies suggest a correlation be...
Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion [0.03%]
STAT3基因的单核苷酸多态性影响AITD易感性、甲状腺自身抗体水平及IL6和IL17分泌
Agnieszka Kotkowska,Ewa Sewerynek,Daria Domańska et al.
Agnieszka Kotkowska et al.
STAT3 (signal transducer and activator of transcription 3) is an important cellular effector in the Jak/STAT signaling pathway, which plays a pivotal role in human immune system regulation, mediating the effect of different cytokines. In th...
Wan Ning Vanessa Chow,Hei Nga Maggie Cheung,Wen Li et al.
Wan Ning Vanessa Chow et al.
FE65 is a brain-enriched, developmentally regulated adaptor protein that was first identified as a binding partner of amyloid precursor protein (APP), an important molecule in Alzheimer's disease. FE65 possesses three protein interaction do...