The effect of nicotine on the expressions of the α7 nicotinic receptor gene and Bax and Bcl-2 proteins in the mammary gland epithelial-7 breast cancer cell line and its relationship to drug resistance [0.03%]
尼古丁对乳腺癌MCF-7细胞α7烟碱型乙酰胆碱受体基因及其与凋亡相关蛋白Bax和Bcl-2表达的影响及与耐药性的关系研究
Naghmeh Aali,Gholamreza Motalleb
Naghmeh Aali
The binding of nicotine with nicotinic acetylcholine receptors (nAChRs) stimulates cell division and increases drug resistance in cancer. Experiments with specific inhibitors such as RNAi, hexamethonium, and α-bungarotoxin showed that α7 ...
The cloning, expression and purification of recombinant human neuritin from Escherichia coli and the partial analysis of its neurobiological activity [0.03%]
大肠杆菌中重组人神经蛋白的克隆、表达及纯化及其部分神经生物学活性分析
Yuanyuan Li,Juan Tang,Yunhua Zhang et al.
Yuanyuan Li et al.
Neuritin (Nrn1) is a neurotrophic factor that plays various roles in neural development and synaptic plasticity. In this study, the NRN1 gene was cloned and expressed in Escherichia coli and then recombinant neuritin protein was purified so...
The effect of cultureware surfaces on functional and structural components of differentiated 3T3-L1 preadipocytes [0.03%]
培养基表面如何影响分化3T3-L1前脂肪细胞的功能和结构组件
Nela Pavlikova,Martin Weiszenstein,Jan Pala et al.
Nela Pavlikova et al.
Experiments using cultured primary cells or cell lines are a routine in vitro approach used across multiple biological disciplines, However, the structural and functional influences of various cultureware materials on cultured cells is not ...
Ramipril inhibits high glucose-stimulated up-regulation of adhesion molecules via the ERK1/2 MAPK signaling pathway in human umbilical vein endothelial cells [0.03%]
雷米普利通过抑制ERK1/2信号通路减少葡萄糖诱导的人脐静脉内皮细胞粘附分子的表达
Moo Hyun Kim,Hae Min Kang,Chae-Eun Kim et al.
Moo Hyun Kim et al.
Ramipril has recently been shown to have anti-atherogenic properties. However, the specific mechanisms underlying these effects remain unclear. The purpose of this study was to determine the effects of ramipril on induction of adhesion mole...
Proteasomes raise the microtubule dynamics in influenza A (H1N1) virus-infected LLC-MK2 cells [0.03%]
蛋白酶体可促进流感A(H1N1)病毒在LLC-MK2细胞中感染时的微管动态变化
Flora De Conto,Carlo Chezzi,Alessandra Fazzi et al.
Flora De Conto et al.
The dynamics of microtubule networks are known to have an impact on replication of influenza A virus in some cellular models. Here we present evidence suggesting that at late stages of LLC-MK2 cell infection by influenza A (H1N1) virus the ...
Kamila Puchałowicz,Irena Baranowska-Bosiacka,Violetta Dziedziejko et al.
Kamila Puchałowicz et al.
Purinergic signaling in the nervous system has been the focus of a considerable number of studies since the 1970s. The P2X and P2Y receptors are involved in the initiation of purinergic signaling. They are very abundant in the central and p...
MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death [0.03%]
凋亡相关淋巴细胞死亡诱导的内源性毒性蛋白释放及机制研究
Qingpan Bu,Jianhui Wang,Yi Zheng et al.
Qingpan Bu et al.
Macrophage galactose-type lectin (MGL) participates in the regulation of T cell apoptosis, but the exact death pathway remains unclear. Here, we demonstrated that MGL-induced T cell death occurs in a caspase-independent manner. Furthermore,...
Cerivastatin represses atherogenic gene expression through the induction of KLF2 via isoprenoid metabolic pathways [0.03%]
他汀类药物抑制动脉粥样硬化基因表达的机制研究
Jiyuan Zhao,Selvamuthu K Natarajan,Nicolas Chronos et al.
Jiyuan Zhao et al.
Earlier clinical studies have reported that cerivastatin has an anti-atherosclerotic effect that is unique among the statins. In our study, human THP-1 macrophage cells were used to study the effects of various statins on the expressions of...
Shuang-Yang Tang,Yan-Ping Wan,Yi-Mou Wu
Shuang-Yang Tang
Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell surv...
Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does [0.03%]
基因插入靶向载体的同源臂及CRISPR/Cas9技术：长度无关紧要；目标克隆的质量控制很重要
Silvia Petrezselyova,Slavomir Kinsky,Dominika Truban et al.
Silvia Petrezselyova et al.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) technology has brought rapid progress in mammalian genome editing (adding, disrupting or changing the sequence of specific sites) by increasing th...