MITF and PU.1 inhibit adipogenesis of ovine primary preadipocytes by restraining C/EBPβ [0.03%]
MITF和PU.1通过抑制C/EBPβ的表达抑制羊原代前脂肪细胞的分化
ChongMei Ruan,Xiu Li,JunJie Hu et al.
ChongMei Ruan et al.
Background: PU box-binding protein (PU.1) is a master gene of hematopoietic lineage and an important specific transcription factor in osteoclast lineage. There is proof of its expression in adipose tissue, and it is known...
Avoiding the side effects of electric current pulse application to electroporated cells in disposable small volume cuvettes assures good cell survival [0.03%]
避免电流脉冲作用于一次性小体积比色皿中的电穿孔细胞以保证良好的细胞存活率
Maciej Grys,Zbigniew Madeja,Włodzimierz Korohoda
Maciej Grys
Background: The harmful side effects of electroporation to cells due to local changes in pH, the appearance of toxic electrode products, temperature increase, and the heterogeneity of the electric field acting on cells in...
p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation [0.03%]
泛素化蛋白质降解时连接自噬途径与泛素-蛋白酶体系统的P62
Wei Jing Liu,Lin Ye,Wei Fang Huang et al.
Wei Jing Liu et al.
The ubiquitin-proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body of evidence indicates that ubi...
Framework to function: mechanosensitive regulators of gene transcription [0.03%]
力学信号转导的基因转录调节机制框架分析
Megan Finch-Edmondson,Marius Sudol
Megan Finch-Edmondson
Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were considered in the past to be a cons...
IgG silencing induces apoptosis and suppresses proliferation, migration and invasion in LNCaP prostate cancer cells [0.03%]
沉默IgG诱导LNCaP前列腺癌细胞凋亡并抑制其增殖、迁移和侵袭能力
Yawen Xu,Binshen Chen,Shaobo Zheng et al.
Yawen Xu et al.
Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored the role of IgG in the proliferation, apoptosis, cell cycle and in vitro invasive properties of LNCaP prostate cancer cells. We used IGHG1...
The Characteristics Of Human Bone-Derived Cells (HBDCS) during osteogenesis in vitro [0.03%]
体外成骨过程中人骨源细胞(HBDCs)的特性研究
Edyta Wrobel,Joanna Leszczynska,Edyta Brzoska
Edyta Wrobel
Background: The primary human bone-derived cell culture technique is used as a model to study human osteogenesis. Compared to cell line cultures, primary osteoprogenitor and osteoblast cultures provide more complex inform...
The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner [0.03%]
人aldo-keto还原酶AKR7A2作为细胞球蛋白结合伙伴的鉴定
Xin Li,Shanshan Zou,Zhen Li et al.
Xin Li et al.
Cytoglobin (CYGB), a member of the globin family, is thought to protect cells from reactive oxygen and nitrogen species and deal with hypoxic conditions and oxidative stress. However, its molecular mechanisms of action are not clearly under...
Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway [0.03%]
微小弯颈菌抑制内皮细胞增殖的机制研究
Enze Jin,Seongho Han,Mina Son et al.
Enze Jin et al.
Cordyceps belongs to a genus of acormycete fungi and is known to exhibit various pharmacological effects. The aim of this study was to investigate the effect of Cordyceps species on the proliferation of vascular smooth muscle cells (VSMC) a...
Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator [0.03%]
密码偏爱与囊性纤维化跨膜转导调节器的折叠动力学关系研究
Rafal Bartoszewski,Jaroslaw Króliczewski,Arkadiusz Piotrowski et al.
Rafal Bartoszewski et al.
Synonymous or silent mutations are often overlooked in genetic analyses for disease-causing mutations unless they are directly associated with potential splicing defects. More recent studies, however, indicate that some synonymous single po...
Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo [0.03%]
无血清培养对滋养细胞系HTR-8/SVneo蛋白质表达的影响
Susana Novoa-Herran,Adriana Umaña-Perez,Francesc Canals et al.
Susana Novoa-Herran et al.
Background: How nutrition and growth factor restriction due to serum depletion affect trophoblast function remains poorly understood. We performed a proteomic differential study of the effects of serum depletion on a firs...