Sen-Yu Zhang,Yu-Hang Yang,Ri Wen et al.
Sen-Yu Zhang et al.
Aging is a primary risk factor driving the increased prevalence of cardiovascular diseases, significantly contributing to global mortality and healthcare burdens. Aging-related alterations, including genomic instability, telomere shortening...
KIAA1429-mediated M6A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis [0.03%]
KIAA1429介导的m6A甲基化通过稳定Lrp4 mRNA抑制破骨细胞分化并预防骨质疏松症
Jincheng Liu,Qingyang Fu,Mengli Li et al.
Jincheng Liu et al.
N6-methyladenosine (m6A) is a novel epigenetic modification that has been reported to be involved in the progression of osteoporosis (OP), providing new insights into the pathogenesis of OP. The methyltransferases KIAA1429 [also known as vi...
Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough [0.03%]
癌细胞穿出血管内皮过程中内皮细胞活化：生死之吻与治疗突破之间的抉择
Katarzyna Piwowarczyk,Zbigniew Madeja,Maciej Siedlar et al.
Katarzyna Piwowarczyk et al.
Cancer development is a complex process, initiated by the combination of epigenetic and genetic changes in normal cells. Selective microenvironmental pressure within the primary tumors prompts the microevolution of invasive cell lineages th...
Multi-omics analyses integration reveals a novel TRF2-miR-181a-5p-S100A10 regulatory axis in colon cancer [0.03%]
多组学分析整合揭示了TRF2-miR-181a-5p-S100A10在结肠癌中的新调控轴
Roberto Dinami,Eleonora Petti,Paola Ostano et al.
Roberto Dinami et al.
Background: The Telomeric repeat-binding factor 2 (TRF2) binds to TTAGGG repeats located at chromosomes ends and ensures telomere protection together with the other members of shelterin. In addition to its well-known role...
Runx2 downregulates Lpl expression through super-silencer formation to alter lipid metabolism in Zhu Schwann cells after nerve injury [0.03%]
Runx2通过形成超级沉默子下调Lpl表达以改变巨鼠施万细胞的脂质代谢表型及功能
Zhaowei Zhu,Rui Kuang,Shouwen Su et al.
Zhaowei Zhu et al.
Background: Phenotypic transformation of Schwann cells (SCs) plays a crucial role in nerve regeneration. Previous studies have demonstrated that Runx2 significantly influences the biological behavior of SCs. Nonetheless, ...
YAP contributes to liver injury through mediating capillarization of liver sinusoidal endothelial cells via GATA6/eNOS signaling [0.03%]
YAP通过GATA6/eNOS信号介导肝窦内皮细胞毛细血管化从而促进肝脏损伤
Junjun Wang,Zhenyang Shen,Guangwen Chen et al.
Junjun Wang et al.
Background: Capillarization of liver sinusoidal endothelial cells (LSECs) is a central event in response to liver injury. In this study, we investigated the role of Yes-associated protein 1 (YAP1, also known YAP) in LSEC ...
AXL activation governs the liver microenvironment to protect ischemia-reperfusion injury by suppressing NLRP3 inflammasome [0.03%]
AXL活化通过抑制NLRP3炎性小体保护缺血再灌注损伤肝脏微环境
Deng Liu,Mengting Zhan,Lei Yao et al.
Deng Liu et al.
Background: Ischemia-reperfusion (I/R) injury frequently arises during liver surgery and significantly contributes to postoperative liver failure and graft dysfunction. Macrophage-mediated pyroptosis cascade plays a cruci...
Inhibition of DHHC9-mediated CD36 palmitoylation lessens high-fat diet (HFD)-induced impairment of pubertal mammary gland development through the JNK-ERK pathway [0.03%]
DHHC9介导的CD36棕榈酰化抑制通过JNK-ERK通路减轻高脂饮食(HFD)对青春期乳腺发育的损害
Yiming Fu,Fenglin Zhang,Limin Lang et al.
Yiming Fu et al.
Background: CD36, a vital fatty acid translocase, has been reported to participate in multiple physiological functions through palmitoylation mediated by zinc finger Asp-His-His-Cys-type palmitoyltransferases (DHHCs). Thi...
Epitranscriptomic modifications in programmed cell death: mechanistic insights and implications for liver diseases [0.03%]
程序性细胞死亡中的表转录组修饰：机制见解及其对肝病的影响
Lulu Chen,Yajuan Lu,Aoli Deng et al.
Lulu Chen et al.
Epitranscriptomic modifications, as a dynamic and reversible system of chemical modifications, have emerged as a key regulatory hub for programmed cell death (PCD) by finely modulating the RNA metabolic network. During the pathological prog...
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region [0.03%]
长链非编码RNA样MMP14通过在STARD13启动子区域抑制H3K27me3来促进结直肠癌转移
Mengting Li,Ying Gao,Xiaolin Sun et al.
Mengting Li et al.
Background: MMP14 protein has been recognized to promote tumor metastasis through protease activity, yet drugs targeting the protein fail to improve survival rates, suggesting the presence of non-protein regulatory mechan...