Y-chromosome alteration and its impact on cancer progression and metastasis [0.03%]
染色体变异及其对癌症进展和转移的影响
Sarah Ann King,Merana Jahan,Prathiksha Prabhakaraalva et al.
Sarah Ann King et al.
The human Y chromosome (ChrY), which confers male sex determination, contains a relatively small number of protein-coding genes compared to other chromosomes; consequently, its functional impact on adult physiology was once severely unappre...
lncRNA IGFL2-AS1 mediates NSCLC chemoresistance via YBX1-induced HSPA1A/RAP1 activation [0.03%]
长链非编码RNA IGFL2-AS1通过YBX1诱导的HSPA1A/RAP1活化介导非小细胞肺癌的化学耐药性
Hongliang Dong,Yunxiu Xia,Jingjing Qi et al.
Hongliang Dong et al.
Background: The development of drug resistance in cancer is associated with multiple malignant properties, including proliferative progression, metastasis, and stemness. Long noncoding RNAs (lncRNAs) reportedly contribute...
The ISGylation tapestry in cancer: weaving phenotypic plasticity through multidimensional regulatory looms [0.03%]
癌症中的ISGylation图谱：通过多维度调控织机编织表型可塑性
Ruicheng Wu,Fanglin Shao,Siang Boon Koh et al.
Ruicheng Wu et al.
Post-translational modification is an important mechanism for regulating protein function and cell signaling networks. Among these modifications, ISGylation is a ubiquitin-like modification regulated by ISG15. In this review, we explore the...
Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism [0.03%]
角膜上皮再生的表观转录组调控机制研究
Nadège Feret,Alicia Caballero Megido,Alison Kuony et al.
Nadège Feret et al.
Background: Rapid and efficient epithelial regeneration is fundamental for tissue homeostasis and proper function. As the outermost ocular structure, the cornea is transparent, multilayered, and vital for clear vision. Du...
MicroRNA strand ratio disarray promotes temozolomide resistance in glioblastoma [0.03%]
微小核糖核酸链比率异常通过促进胶质母细胞瘤替莫唑胺耐药
Fangfang Shen,Pengfei Wu,Zelian Li et al.
Fangfang Shen et al.
Background: Disarray in microRNA (miRNA) strand selection is associated with multiple tumors. However, the mechanisms underlying miRNA strand selection-driven temozolomide (TMZ) resistance in glioblastoma (GBM) remain une...
DGKs in lipid signaling and disease intervention: structural basis, pathological mechanisms, and emerging therapeutic strategies [0.03%]
DGK在脂质信号转导和疾病干预中的作用：结构基础、病理机制及新兴治疗策略
Jifeng Liu,Jingyuan Ma,Yunshu Zhang et al.
Jifeng Liu et al.
Diacylglycerol kinases (DGKs) are crucial lipid-signaling enzymes that convert diacylglycerol (DAG) into phosphatidic acid (PA) through phosphorylation. This reaction modulates the DAG-PA axis, which is central to signal transduction, metab...
FGF21 confers neuroprotection in Parkinson's disease by activating the FGFR1-sirt1 pathway [0.03%]
FGF21通过激活FGFR1-sirt1通路在帕金森病中赋予神经保护作用
Tingting Liu,Jianshe Wei
Tingting Liu
Background: Parkinson's disease (PD) lacks disease-modifying therapies. Fibroblast growth factor 21 (FGF21) is implicated in PD, but its neuroprotective mechanisms via fibroblast growth factor receptor 1 (FGFR1)-sirtuin 1...
Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/β-catenin axis [0.03%]
Circular RNA circSLC39A10通过miR-936/PROX1/β-catenin轴激活Wnt信号促进前列腺癌进展
Kailai Chen,Xiang Pan,Shiheng Zhang et al.
Kailai Chen et al.
Circular RNAs (circRNAs) play a crucial role in the initiation and development of cancers. Understanding circRNAs' functions and molecular mechanisms in tumor development is expected to reveal new diagnostic indicators and therapeutic targe...
PPARγ-Axl axis ameliorates intervertebral disc degeneration by activating PI3K/AKT-mediated autophagy to suppress ferroptosis [0.03%]
PPARγ-Axl轴通过激活PI3K/AKT介导的自噬来抑制铁死亡从而改善椎间盘退变
Guantong Sun,Derong Xu,Yichen Jiang et al.
Guantong Sun et al.
Peroxisome proliferator-activated receptors (PPARs) play a critical role in the development of intervertebral disc degeneration (IVDD), a major contributor to chronic low back pain (LBP). This condition is characterized by excessive nucleus...
ID1 in hematopoiesis and hematologic disorders: novel potentials of a classic differentiation regulator [0.03%]
ID1在造血及血液系统疾病中的作用：经典分化调节因子的新潜力
Yangjing Zhao,Jiaxin Xu,Yue You et al.
Yangjing Zhao et al.
The basic helix-loop-helix (bHLH) transcription factor family plays a crucial role in regulating cellular differentiation and development. Inhibitor of DNA binding 1 (ID1), which lacks a DNA-binding motif, functions as a dominant-negative i...