DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives [0.03%]
DNA、RNA和组蛋白甲基化调控酶及其互作在结直肠癌发生发展中的作用：分子机制、临床意义及未来前景综述
Sangni Qian,Hao Song,Lu Huang et al.
Sangni Qian et al.
Colorectal cancer (CRC) ranks among the most common malignant cancers of the digestive system, and its initiation and progression are closely related to both genetic and epigenetic mechanisms. Three major forms of modifications, viz. DNA me...
CUEDC1 promotes glycolytic metabolism reprogramming through the CUEDC1/CACNG4/PI3K axis to promote ER-positive breast cancer growth [0.03%]
CUEDC1通过CUEDC1/CACNG4/PI3K轴促进糖酵解代谢重编程以促进雌激素受体阳性乳腺癌生长
Zexiu Lu,Ming Lei,Jian Chen et al.
Zexiu Lu et al.
Background: The reprogramming of energy metabolism, particularly glycolysis, upholds the malignancy of tumors. The relationship between CUE domain-containing protein-1 (CUEDC1) and glycolysis, along with its influence on ...
CD209a regulates metabolic dysfunction-associated steatotic liver disease development through macrophage STAT3 signaling pathway [0.03%]
CD209a通过巨噬细胞STAT3信号通路调节代谢紊乱相关肝脂肪变性疾病的发病发展
Yishu Chen,Jiaming Zhou,Chenxi Tang et al.
Yishu Chen et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with macrophage-driven inflammation playing a critical role in its progression. CD209a, a C-type lectin rece...
Loss of alpha-kinase 1 contributes to the formation of congenital cataracts in mice [0.03%]
AK1缺乏通过影响γδ晶状上皮细胞的凋亡促进小鼠先天性白内障形成
Hui-Shan Wang,Yu-Xin Yang,Shang-Shang Duan et al.
Hui-Shan Wang et al.
Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging [0.03%]
胆固醇-胆固醇酯代谢异常损害卵巢衰老过程中的卵母细胞质量
Sainan Zhang,Bichun Guo,Junshun Fang et al.
Sainan Zhang et al.
Background: Ovarian aging-induced decline in oocyte quality has been a main issue in women of advanced maternal age. However, the potential mechanism remains elusive, and there are no effective strategies to ameliorate ag...
Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression [0.03%]
具核梭杆菌来源的携带毒力因子DNA的胞外囊泡通过激活AIM2炎性小体促进溃疡性结肠炎发展
Yuqing Zhao,Rui Wu,Yaqian Duan et al.
Yuqing Zhao et al.
Background: Immune disorders and impaired intestinal barrier function resulting from dysbiosis of the intestinal flora play pivotal roles in the pathogenesis of ulcerative colitis (UC). Fusobacterium nucleatum (F. nucleat...
Human umbilical cord mesenchymal stromal cell-derived exosomes alleviate antibiotic-induced intestinal barrier damage by regulating autophagy via the S100G/mTOR signaling pathway [0.03%]
人源脐带间充质干细胞外泌体通过S100G/mTOR信号通路调节自噬来缓解抗生素诱导的肠屏障损伤
Yanji Guo,Yanpeng Li,Meng Shi et al.
Yanji Guo et al.
Background: Antibiotics are a double-edged sword. Long-term, broad-spectrum, and high-dose antibiotic use can lead to the occurrence of related diseases, particularly attracting attention in the context of intestinal barr...
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis [0.03%]
CDK5通过调节巨噬细胞极化和软骨细胞凋亡来调控PPARγ/NF-κB信号通路从而加重肥胖相关性骨关节炎
Yusheng Li,Hengzhen Li,Xin Chen et al.
Yusheng Li et al.
Background: Obesity is an important risk factor for osteoarthritis (OA), but the mechanisms associated with OA progression are still not fully understood. The aim of this study was to investigate the role of cyclin-depend...
E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes [0.03%]
E0703通过靶向ERβ促进GLI3上调，从而缓解辐射引起的淋巴细胞DNA损伤
Zebin Liao,Liangliang Zhang,Zekun Wu et al.
Zebin Liao et al.
Background: Radiotherapy for malignant tumor treatment and irradiation (IR)-related diagnosis damage lymphocytes, which inevitably suppresses immunity and leads to unwanted clinical outcomes. However, a few agents have be...
Cellular osmoregulation enhances porcine embryo development by restoring zygotic genome activation via metabolic-epigenetic crosstalk [0.03%]
基于代谢表观遗传互作的细胞渗透压调节通过恢复卵裂球基因组激活促进猪胚胎发育
Xiangyuan Zhao,Lixiang Liu,Xiaoyu Chu et al.
Xiangyuan Zhao et al.
Introduction: In vitro embryo culture is essential for human assisted reproduction and livestock breeding, yet its efficiency remains limited owing to developmental arrest triggered by suboptimal media composition and env...