Beyond the mutations: spatiotemporal regulation of CFTR by cAMP and calcium signaling in epithelial physiology and cystic fibrosis [0.03%]
cAMP和钙信号调控上皮生理学和囊性纤维化中CFTR的时空机制超越了突变体本身
Arpad Varga,Aletta Kiss,Tim Crul et al.
Arpad Varga et al.
Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the CFTR gene, but the functional expression of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-/HCO3- channel is determined by more than i...
SLC25A39 identified as a key regulator of hepatocellular carcinoma progression through the mitochondrial ROS-cytochrome c-caspase signaling axis [0.03%]
SLC25A39通过线粒体ROS-细胞色素c-caspase信号轴被鉴定为肝癌进展的关键调节因子
Manqiu Yuan,Meng Du,Jiachi Yu et al.
Manqiu Yuan et al.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, underscoring the urgent demand for novel diagnostic and therapeutic targets. While mitochondrial carriers (MCs) pla...
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation [0.03%]
PCSK9抑制剂通过SIRT6调节改善微塑料引起的内皮氧化还原失衡
Nunzia D&#x;Onofrio,Isabella Donisi,Vitale Del Vecchio et al.
Nunzia D&#x;Onofrio et al.
Background: Microplastics (MPs) have emerged as significant environmental pollutants, posing a threat to ecosystems and humans. The presence of MPs in atherosclerotic plaques, exacerbating cardiovascular risk, has been re...
The cancer-testis lncRNA LINC01940 promotes gastric cancer malignant progression and chemoresistance by enhancing ribosome biogenesis via TAF15-mediated NOL11 SUMOylation [0.03%]
癌症-睾丸长链非编码RNA LINC01940通过TAF15介导的NOL11 SUMO化促进核糖体生物发生从而促进胃癌恶性进展和化学抗性
Weijie Zang,Debiao Fan,Zhuang Lu et al.
Weijie Zang et al.
Background: Aberrant ribosome biogenesis promotes gastric cancer (GC) progression and contributes to chemoresistance by sustaining protein synthesis, upon which GC cell survival depends. However, the regulatory role of ca...
CDCP1 allosterically regulates the AMPK α1 subunit to enhance fatty acid oxidation in osteoblasts [0.03%]
CDCP1通过别构调节AMPKα1亚基增强成骨细胞中的脂肪酸氧化
Xiang Li,Weichun Zhu,Jinlong Ma et al.
Xiang Li et al.
A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolism [0.03%]
一种新的tRF-Gly通过脂质代谢的转录后调控与肥胖发病机制相关联
Yuhang Lei,Mailin Gan,Kai Wang et al.
Yuhang Lei et al.
Background: Obesity, characterized by excessive fat accumulation, represents a global health crisis closely linked to metabolic disorders such as type 2 diabetes, hypertension, and atherosclerosis. tRNA-derived small RNAs...
Ribosomal protein RPL7A modulates lung adenocarcinoma progression via circRANBP17-UPF1-mediated SIRT6 degradation [0.03%]
核糖体蛋白RPL7A通过circRANBP17-UPF1介导的SIRT6降解调节肺腺癌进展
Yichen Zhu,Jing Han,Yan Pan et al.
Yichen Zhu et al.
Background: Lung cancer, primarily lung adenocarcinoma (LUAD), is the leading cause of cancer-related deaths worldwide. Despite extensive research, the mechanisms behind LUAD progression remain inadequately understood, un...
The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis [0.03%]
新的环状RNA circG6pc通过miR-7018-5p/Aldh6a1轴减轻肾纤维化中的氧化应激和线粒体损伤
Xiaojie Zhao,Yufeng Xiong,Xuke Qin et al.
Xiaojie Zhao et al.
Background: Chronic kidney disease (CKD) is characterized by progressive renal fibrosis, which contributes to disease progression and ultimately leads to kidney failure. Circular RNAs (circRNAs) are key regulators in vari...
tsRNA-3040b accumulates R-loop to regulate Trim35 transcription, which leads to disordered glycolysis and promotes PAECs proliferation [0.03%]
tsRNA-3040b通过积累R环调节Trim35转录，导致糖酵解紊乱并促进PAECs增殖
Xu Wang,Songyue Li,Jianli Hou et al.
Xu Wang et al.
Background: Hypoxia significantly influences the development of pulmonary hypertension (PH). However, the role of transfer RNA-derived small RNAs (tsRNAs) produced by nuclease cleavage on PH, particularly their impact on ...
Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca2+ signaling [0.03%]
三叉神经根受压诱发的神经炎症反应通过CGRP/SP-Piezo2介导的钙信号促进机械性痛觉过敏
Xinyue Liao,Zhaoke Luo,Feng Huang et al.
Xinyue Liao et al.