Canadian pregnancy outcomes in rheumatoid arthritis and systemic lupus erythematosus [0.03%]
加拿大类风湿性关节炎和系统性红斑狼疮的妊娠结局
Cheryl Barnabe,Peter D Faris,Hude Quan
Cheryl Barnabe
Objective. To describe obstetrical and neonatal outcomes in Canadian women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Methods. An administrative database of hospitalizations for neonatal delivery (1998-2009) from ...
Toshiyuki Yamamoto,Ichiro Katayama
Toshiyuki Yamamoto
Systemic sclerosis (SSc) is characterized by vascular injury, immunological abnormalities, and fibrosis of the skin as well as various internal organs. Vascular impairment is the early manifestation and plays a fundamental role in the patho...
Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis: The Difficulty in Interpreting Proof-of-Concept Studies [0.03%]
酪氨酸激酶抑制剂治疗系统性硬化病的难点在于诠释概念验证试验的结果
Jessica Gordon,Robert Spiera
Jessica Gordon
Tyrosine kinase inhibitors (TKIs) have emerged as a targeted therapy of interest for the treatment of systemic sclerosis (SSc). Recently, several groups have performed pilot or "proof-of-concept" studies to determine the feasibility of this...
Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease [0.03%]
通过抑制αvβ6整合素阻断TGFβ可能是系统性硬化症间质性肺病的治疗策略
Tamiko R Katsumoto,Shelia M Violette,Dean Sheppard
Tamiko R Katsumoto
Interstitial lung disease (ILD) is a commonly encountered complication of systemic sclerosis (SSc) and accounts for a significant proportion of SSc-associated morbidity and mortality. Its pathogenesis remains poorly understood, and therapie...
Riccardo Chiusaroli,Tiziana Piepoli,Tiziano Zanelli et al.
Riccardo Chiusaroli et al.
Several clinical studies demonstrated that glucosamine sulfate (GS) is effective in controlling osteoarthritis (OA), showing a structure-modifying action. However, little is known about the molecular mechanism(s) by which GS exerts such act...
Anti-α-enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights [0.03%]
儿科炎症性疾病患者血清中抗丙酮酸羧化酶自身抗体的诊断及病理机制研究
Alessandra Pontillo,Nicola Di Toro,Paolo Edomi et al.
Alessandra Pontillo et al.
Human glycolytic enzyme α-enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti-α-enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the pu...
Skin autofluorescence, as marker of accumulation of advanced glycation endproducts and of cumulative metabolic stress, is not increased in patients with systemic sclerosis [0.03%]
皮肤自体荧光（反映晚期糖基化终产物蓄积和累积性代谢压力的指标）在系统性硬化症患者中无增高现象
M E Hettema,H Bootsma,R Graaff et al.
M E Hettema et al.
Objective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Meth...
The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis [0.03%]
多面体的白细胞介素6：IL-6在炎症、血管病和系统性硬化症纤维化中的作用
Theresa C Barnes,Marina E Anderson,Robert J Moots
Theresa C Barnes
Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is ex...
Tracy Frech,Kirsten Novak,Monica P Revelo et al.
Tracy Frech et al.
Pruritus is a common symptom in systemic sclerosis (SSc), an autoimmune disease which causes fibrosis and vasculopathy in skin, lung, and gastrointestinal tract (GIT). Unfortunately, pruritus has limited treatment options in this disease. P...
Apoptosis modulation as a promising target for treatment of systemic sclerosis [0.03%]
凋亡调控作为系统性硬化症治疗的靶点具有良好的前景
Stéphane Chabaud,Véronique J Moulin
Stéphane Chabaud
Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vas...