Courtney L Kraus,Susan M Culican
Courtney L Kraus
Biologic agents have dramatically shifted the treatment paradigm for rheumatic disease. Use of these agents can decrease disease burden, allow the patient to be weaned from corticosteroids, and reduce the likelihood of relapse. Eye disease ...
Primary biliary cirrhosis associated with systemic sclerosis: diagnostic and clinical challenges [0.03%]
与系统性硬化症相关的原发性胆汁性肝硬化：诊断和临床挑战
Cristina Rigamonti,Dimitrios P Bogdanos,Maria G Mytilinaiou et al.
Cristina Rigamonti et al.
Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible ...
Cost effectiveness analysis of disease-modifying antirheumatic drugs in rheumatoid arthritis. A systematic review literature [0.03%]
改善病情抗风湿药治疗类风湿性关节炎的 cost-effectiveness 分析系统综述研究
Maurizio Benucci,Gianantonio Saviola,Mariangela Manfredi et al.
Maurizio Benucci et al.
The cost effectiveness of treatments that have changed the "natural history" of a chronic progressive disease needs to be evaluated over the long term. Disease-modifying antirheumatic drugs (DMARDs) are the standard treatment of rheumatoid ...
A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis [0.03%]
呼吸系统的病变：缺氧如何可能促成了系统性硬化病的发病机制
T W van Hal,L van Bon,T R D J Radstake
T W van Hal
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular alterations and immunological disturbances and fibrosis, the order of which remains to be fully determined. Clinically, patients show clear signs of hypoxia in skin...
The role of intravenous immunoglobulin preparations in the treatment of systemic sclerosis [0.03%]
静脉注射免疫球蛋白制剂在系统性硬化病治疗中的作用
Marta Baleva,Krasimir Nikolov
Marta Baleva
Scleroderma is progressive autoimmune disease associated with severe disability. The major underlying pathological process in scleroderma is progressive development of fibrous tissue and obliteration of the microvasculature. Currently, ther...
PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers: Current Status of Clinical Trials [0.03%]
Phosphodiesterase-5抑制剂治疗系统性硬化症雷诺现象和数字溃疡的临床试验现状
Ann J Impens,Kristine Phillips,Elena Schiopu
Ann J Impens
Systemic sclerosis- (SSc-) related vasculopathy, as manifested by Raynaud's Phenomenon (RP) and digital ulcers (DUs), is associated with significant impairment of the quality of life and morbidity. The current vasoactive approach for SSc-RP...
Jill Johnson,Chris T Derk
Jill Johnson
Gastric antral vascular ectasia is a not so well-understood, and more rare, gastrointestinal manifestation of Systemic Sclerosis which can lead to chronic anemia. A high suspicion and better understanding of this rare manifestation is neede...
Basal Activation of Type I Interferons (Alpha2 and Beta) and 2'5'OAS Genes: Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis [0.03%]
I型干扰素（α2和β）和2'5'OAS基因的基线活化：系统性硬化症中干扰素体系成分差异表达谱研究的新见解
Danilo Bretas de Oliveira,Gabriel Magno de Freitas Almeida,Antônio Carlos Martins Guedes et al.
Danilo Bretas de Oliveira et al.
Objective. Systemic sclerosis (SSc) is a complex autoimmune disease in which interferons (IFNs) may play an essential role. We hypothesized that type I and III IFNs may be found in increased levels in patients and be responsible for SSc aut...
Naoki Miyoshi,Naoki Suenaga,Kou Katayama et al.
Naoki Miyoshi et al.
We report a classification system based on the changes in shape of the glenoid fossa and on an evaluation of the upward migration of the humeral head, because a simple classification based on X-ray evaluation would be of great assistance to...
Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis [0.03%]
内皮素受体拮抗剂治疗系统性硬化症的雷诺现象和数字溃疡疗效及安全性的系统评价和 meta 分析
Kait Arefiev,David F Fiorentino,Lorinda Chung
Kait Arefiev
Systemic sclerosis is a connective tissue disease characterized by fibrosis of the skin, internal organs, and widespread vasculopathy. Raynaud's phenomenon and digital ulcers are vascular manifestations of this disease and cause significant...