Lily Kao,Cornelia Weyand
Lily Kao
Systemic sclerosis (SSc) is a multiorgan connective tissue disease characterized by autoantibody production and fibroproliferative stenosis of the microvasculature. The vascoluopathy associated with SSc is considered to be noninflammatory, ...
An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes-Methodology and Preliminary Results [0.03%]
一项国际性、基于网络的前瞻性队列研究：探讨血管紧张素转换酶抑制剂的使用与系统性硬化症肾危象结局之间的关系——方法学和初步结果
Marie Hudson,Murray Baron,Ernest Lo et al.
Marie Hudson et al.
Background. To describe the methodology of a study designed to determine whether systemic sclerosis (SSc) patients with incident scleroderma renal crisis (SRC) on angiotensin converting enzyme (ACE) inhibitors prior to the onset of SRC have...
Characteristics of interstitial fibrosis and inflammatory cell infiltration in right ventricles of systemic sclerosis-associated pulmonary arterial hypertension [0.03%]
系统性硬化症相关肺动脉高压右心室间质纤维化和炎症细胞浸润的特征
Maria J Overbeek,Koen T B Mouchaers,Hans M Niessen et al.
Maria J Overbeek et al.
Objective. Systemic sclerosis-associated pulmonary arterial hypertension (SScPAH) has a disturbed function of the right ventricle (RV) when compared to idiopathic PAH (IPAH). Systemic sclerosis may also affect the heart. We hypothesize that...
Serum endoglin levels in patients suffering from systemic sclerosis and elevated systolic pulmonary arterial pressure [0.03%]
系统性硬化病患者血清内皮素水平及其与收缩期肺动脉压升高的关系
Paola Ximena Coral-Alvarado,Maria Fernanda Garces,Jorge Eduardo Caminos et al.
Paola Ximena Coral-Alvarado et al.
Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients w...
Umaima Marvi,Lorinda Chung
Umaima Marvi
Digital ischemic loss is a cause of significant morbidity in patients with systemic sclerosis (SSc). Microvascular disease with intimal proliferation and luminal narrowing of small digital arteries, as well as macrovascular disease with nar...
Elena Schiopu,Ann J Impens,Kristine Phillips
Elena Schiopu
Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the...
Identification of myocardial damage in systemic sclerosis: a nuclear cardiology approach [0.03%]
系统性硬化症心肌损害的核素心血管影像识别研究
Kenichi Nakajima,Shinro Matsuo,Minoru Hasegawa et al.
Kenichi Nakajima et al.
Myocardial involvement is an important prognostic factor in patients with systemic sclerosis, and early diagnosis and staging of the disease have been sought after. Since myocardial damage is characterized by connective tissue disease, incl...
Felice Galluccio,Marco Matucci-Cerinic
Felice Galluccio
Digital ulcers are a very frequent complication of systemic sclerosis affecting about half of the SSc patients, and about 75% of the affected patients have their first DU episode within 5 years from their first non-Raynaud symptom. The lack...
Capillaroscopy as an Outcome Measure for Clinical Trials on the Peripheral Vasculopathy in SSc-Is It Useful? [0.03%]
毛细血管镜检查能否作为硬皮病外周血管病变临床试验的疗效评定指标？
Maurizio Cutolo,Alberto Sulli,Carmen Pizzorni et al.
Maurizio Cutolo et al.
Peripheral microvascular impairment in systemic sclerosis (SSc) may be easily detected and scored in a safe noninvasive way by nailfold videocapillaroscopy (NVC). The paper highlights clinical conditions related to SSc in which NVC may repr...
Lower extremity ulcers in systemic sclerosis: features and response to therapy [0.03%]
系统性硬化症下肢溃疡的特征及治疗反应
Victoria K Shanmugam,Patricia Price,Christopher E Attinger et al.
Victoria K Shanmugam et al.
Nondigital lower extremity ulcers are a difficult to treat complication of scleroderma, and a significant cause of morbidity. The purpose of this study was to evaluate the prevalence of nondigital lower extremity ulcers in scleroderma and d...